ID A0A370GS96_9NOCA Unreviewed; 752 AA.
AC A0A370GS96;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:RDI46190.1};
GN ORFNames=DFR68_11291 {ECO:0000313|EMBL:RDI46190.1};
OS Nocardia mexicana.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=279262 {ECO:0000313|EMBL:RDI46190.1, ECO:0000313|Proteomes:UP000255355};
RN [1] {ECO:0000313|EMBL:RDI46190.1, ECO:0000313|Proteomes:UP000255355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44952 {ECO:0000313|EMBL:RDI46190.1,
RC ECO:0000313|Proteomes:UP000255355};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDI46190.1}.
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DR EMBL; QQAZ01000012; RDI46190.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370GS96; -.
DR STRING; 1210089.GCA_001613165_03395; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000255355; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000255355};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..334
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 693..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 78661 MW; D843278268F86FB8 CRC64;
MFARLGAVVV HNPWKTIGLW VLIVIAVMAT APKLASTTDQ SDFLPSHYES IQAMELQEKA
FPQSSAPAAI VVFERGDGAP LEAADSAAVE SITAQLRQAG IENVTGIQAA PPSDNRLIQI
AAVQMTKATG ASDTRQSDAV RDLRDALKSK LDGTDLKGGV TGQAAQTLDA TESSEKGMAI
IGIATILLIL VLLLVIFRSP VIALLPILVI GAITGVVNGL IAWVSKGFDL KVDSSVTSIL
LVVLYGVGTD YILFLMFRYR ERLRAGEDPK TAMVSAVTRV GEAITSAAGA VIIAFMALTL
STLGLFKSLG PALAIAVGVA LVAGLTLVPA IVSLLGTKVF WPSKAWRAEP KGAGFAAVGR
GLGKRPGVFA VVSGGVLVVL GLFAVGFSPT FDLTSGSTSN ASESVVYNKE LVKGMPAGVT
QPSDVMLQST GGLTDEQLGA YRDALAAVPG VGQVAEPALS QDRTVADYRV TLASAPESDA
AIDTVAGPLR DAAHAAAPPG TTAAVGGMTA VFVDFQDAMN HDYTVVFPVA AILIMIVLAL
LLRSLVAPWY LMASVFLGFA ATLGASVLVF QHMQGEPGLI FTLPVIMYLF VVALGTDYNI
LMVARLREEA REGNDPHRAA ALAVRHTGPT IVAAGVILAG TFASMMLAGN TMLSEMGFAI
SVGIAIAAFV MALFFTPAVT ALIGHRAWWP GHGDSKPERK GGVPNTGAVQ HDPNWSKYMH
ADTYDHDGVP TVSVPERQGS QWSWSNTGER RR
//
