ID A0A370H0E2_9NOCA Unreviewed; 605 AA.
AC A0A370H0E2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=DNA-3-methyladenine glycosylase II {ECO:0000313|EMBL:RDI49375.1};
GN ORFNames=DFR68_107503 {ECO:0000313|EMBL:RDI49375.1};
OS Nocardia mexicana.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=279262 {ECO:0000313|EMBL:RDI49375.1, ECO:0000313|Proteomes:UP000255355};
RN [1] {ECO:0000313|EMBL:RDI49375.1, ECO:0000313|Proteomes:UP000255355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44952 {ECO:0000313|EMBL:RDI49375.1,
RC ECO:0000313|Proteomes:UP000255355};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDI49375.1}.
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DR EMBL; QQAZ01000007; RDI49375.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370H0E2; -.
DR STRING; 1210089.GCA_001613165_00999; -.
DR Proteomes; UP000255355; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR Gene3D; 3.30.310.20; DNA-3-methyladenine glycosylase AlkA, N-terminal domain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR035451; Ada-like_dom_sf.
DR InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR InterPro; IPR010316; AlkA_N.
DR InterPro; IPR037046; AlkA_N_sf.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR PANTHER; PTHR46796:SF2; HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS; 1.
DR PANTHER; PTHR46796; HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED; 1.
DR Pfam; PF02805; Ada_Zn_binding; 1.
DR Pfam; PF06029; AlkA_N; 1.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM01009; AlkA_N; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF55945; TATA-box binding protein-like; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000255355};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 79..177
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000259|PROSITE:PS01124"
FT REGION 277..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 65294 MW; 4F8CE9C127DFAF2D CRC64;
MCPIPPPRRG HHGDMSTFTG VVTTGIYCRP GCGGRPKPEN VRVFTTAAAA EAAGYRACLR
CRPYRGEPPV GPPGSELVCR AVGLIVDGML DGCGEAELAA RLGASARHLR RLFADSLGIT
PDQLARSSRV HFARRLLDDT DLTVLDVAFA SGFGSVRQLN RAFHESFHAS PTALRKRRRS
TDRLVADGGL LLRLSDRQPL DFEPMLDYLA ERAIPGVEHV DGGTYRRTIT VDGHPGVLEI
FRGPDGSLLL RAHLPDLHGL IHQVRRARHI FALDRTTPTQ PTEDHASNTP LRQPPGTWDA
YETAVRTLVE QGLAQQPTRP THTRPNRPDH TATSNLTPAE TSQLNHTGRN QPDYIATNQP
NNPSANPPDH IDTNQRDHTP TNQPDHTTTN QPNNPSANPP DHIDTNQRDH PDAPGLDHAS
ANPLNHTATN QRDHPDAGLD HASANPLDHA GTNQPDHAGA NQLVGRIVAR HGTAVPGLAP
LGLGYLFPPP RALAEADLTG LDLPSEIART VQTFARAVAE GDIHLDRTQP LHTLLTTLTG
VPGITPATAH YIASRLGEPT TISPPPTGRQ SPNSRTPHTF PHPVQAVVES ARTNTGCANL
RSADQ
//
