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Database: UniProt
Entry: A0A370HCN3_9NOCA
LinkDB: A0A370HCN3_9NOCA
Original site: A0A370HCN3_9NOCA 
ID   A0A370HCN3_9NOCA        Unreviewed;       215 AA.
AC   A0A370HCN3;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:RDI54467.1};
GN   ORFNames=DFR68_102595 {ECO:0000313|EMBL:RDI54467.1};
OS   Nocardia mexicana.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=279262 {ECO:0000313|EMBL:RDI54467.1, ECO:0000313|Proteomes:UP000255355};
RN   [1] {ECO:0000313|EMBL:RDI54467.1, ECO:0000313|Proteomes:UP000255355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44952 {ECO:0000313|EMBL:RDI54467.1,
RC   ECO:0000313|Proteomes:UP000255355};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: TetR is the repressor of the tetracycline resistance element;
CC       its N-terminal region forms a helix-turn-helix structure and binds DNA.
CC       Binding of tetracycline to TetR reduces the repressor affinity for the
CC       tetracycline resistance gene (tetA) promoter operator sites.
CC       {ECO:0000256|ARBA:ARBA00002856}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDI54467.1}.
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DR   EMBL; QQAZ01000002; RDI54467.1; -; Genomic_DNA.
DR   RefSeq; WP_068023822.1; NZ_QQAZ01000002.1.
DR   AlphaFoldDB; A0A370HCN3; -.
DR   STRING; 1210089.GCA_001613165_04846; -.
DR   OrthoDB; 329481at2; -.
DR   Proteomes; UP000255355; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR004111; Repressor_TetR_C.
DR   InterPro; IPR003012; Tet_transcr_reg_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR   PANTHER; PTHR30055:SF151; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF02909; TetR_C_1; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   PRINTS; PR00400; TETREPRESSOR.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000255355}.
FT   DOMAIN          7..67
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        30..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   215 AA;  23682 MW;  CAF2EE771E243EB9 CRC64;
     MPRRPLPLSR DRVLEAAVRV ADRGGAEAIT MRRVAQELGV EAMSLYHHVP NKDAILDGVV
     DVVFAAIELP GGEQDWRGAI RARACSARKV LSRHRWALGL VDSRRNPGPA TLRHHDAVLG
     TLRKAGFTLP MAAHAVSLID SYIGGYVLQE ANLPMTTPAD VEDVAGPLLE ELPPDRFPHL
     REMIVDHALR PGYDHTEEFD YGLDLILDAL EARRG
//
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