ID A0A370HPW4_9NOCA Unreviewed; 712 AA.
AC A0A370HPW4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:RDI58944.1};
GN ORFNames=DFR76_1261 {ECO:0000313|EMBL:RDI58944.1};
OS Nocardia pseudobrasiliensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=45979 {ECO:0000313|EMBL:RDI58944.1, ECO:0000313|Proteomes:UP000254869};
RN [1] {ECO:0000313|EMBL:RDI58944.1, ECO:0000313|Proteomes:UP000254869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44290 {ECO:0000313|EMBL:RDI58944.1,
RC ECO:0000313|Proteomes:UP000254869};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDI58944.1}.
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DR EMBL; QQBC01000026; RDI58944.1; -; Genomic_DNA.
DR RefSeq; WP_068009898.1; NZ_QQBC01000026.1.
DR AlphaFoldDB; A0A370HPW4; -.
DR Proteomes; UP000254869; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000254869};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..366
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 396..701
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 712 AA; 74689 MW; F4253ED66B1D922F CRC64;
MRAWSRLVTS YPRLVIALSV TPLLALGFWG FGVFDRMNLS GYDNPDSDSA RVSRVLDERF
GRAVPDVVVI YRAPAGKTVD DIGAAVIDRI RGVDPRLLAR PIESYWTSAP ALRNALVSSD
RTEALAVATL AGPDARRLAE YPDVVAALRW EGDMKVSGWY ATVSAYNVQA QHDLLLADSI
ALPLTLILLI VIFGSVVAAV LPLTVAGLAI LGALSALRLI SMVSDVSSFA VSLAAILGLG
MGIDYSLFMV SRFREELARG REPEAAAVIT VCTAGRTIVF SVALLVCAFA GFTAIPVAMC
RSVGIAVSVS VGIAAALSVT AIPAVLTLLG GRVDALSWRR GAIARGENRS RRFWTAVAVA
VTDRPWRVAL LAVTILVILI WPCAGLRLGG ITLNGLPPGN PTRVAQEAVA SKFPLAGNGA
TVVLRATGQR PLSGDSVDAF TASVRHVPHV SEVLRVDQSN DLAVLQVVVA GQDFSSTSMG
TVENLRRLPP PPGTTVLVGG SNAVLADTAS AVAASLPEVI AIMIAATVVL LFVAFRSLVL
PIKAVLMSLL GLTASLGVLA WLFQNDARAS LLGATAGPLP APSLAVMIAV IAGLSTDYET
FLVSRIVEAH NSGASTSEAI RTGMGRTGRI ITAAATLLIL VTGAAGTSQI DIMKIAGVGM
AVAIAIDATV VRMLLVPALV ELMGEANWWF PRIPYFVRRR GSAVEEVPVR NR
//
