ID A0A370K301_9GAMM Unreviewed; 1061 AA.
AC A0A370K301;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=DVT68_18945 {ECO:0000313|EMBL:RDI96968.1};
OS Dyella solisilvae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Rhodanobacteraceae; Dyella.
OX NCBI_TaxID=1920168 {ECO:0000313|EMBL:RDI96968.1, ECO:0000313|Proteomes:UP000254711};
RN [1] {ECO:0000313|EMBL:RDI96968.1, ECO:0000313|Proteomes:UP000254711}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DHG54 {ECO:0000313|EMBL:RDI96968.1,
RC ECO:0000313|Proteomes:UP000254711};
RA Gao Z., Qiu L.;
RT "Dyella solisilvae sp. nov., isolated from the pine and broad-leaved mixed
RT forest soil.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDI96968.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QQSY01000008; RDI96968.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370K301; -.
DR OrthoDB; 9757904at2; -.
DR Proteomes; UP000254711; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 447..469
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 475..502
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 538..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 871..889
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 896..918
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 924..949
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 969..990
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1002..1026
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT REGION 1036..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 114410 MW; DEACB69450705396 CRC64;
MSMSHFFIDR PIFSAVISII LVVAGLVAML SLPIAQFPDI APPQVTVTTT YPGASADVVA
QNVAAPIEQQ VNGADNMMYM NSSSSSTGNL TLTVYFNIGT DPSLAQVDVQ NRVNLALPTL
PSEVAAQGVS VQKRSSAFMI VVAVYSPDNS LDLSYVANYT NVYVLDAIKR ISGANQSQIF
GTADYAMRIW LRPDRMAKLG ITVADVQNSI ASQNQQFSAG RIGQAPTPGP VLQTFPIATK
GRMTEPAEFE NIILKGGTNE AGALVRLKDV GRAELASKDY SLRGRYKGKT ATLLAVYQQP
GANALDVAKQ VRATMAELKK SFPPGLDYEI ALDTTEFVQD SINEVLHTLF EAVVLVIIVV
YLFLQSFRAT LVPILAVPVS IIGAFIGMAA FHFSINMLTL FGMVLAIGIV VDDAIVVIEN
VERNMTEFHL PPKEAAKRAM DEVSGPVVAI VLVLLAVFVP VAFLSGITGQ LYKQFAVTIA
ISVVLSGVVA LTLSPALAAL LLKPGSHKKN RFFTWFNKTF DKITEDYGRG AQLAIKRVMA
SLLLIAGMLV ITVGLFRHIP TSFLPVEDQG YLFGAIIMPD AASLDRTGDV SRRASDWFEK
QPGVKSVAEV IGYSLIDSQN KANSGTLFIT LKSFGERGEG QTAADLIREG SKEFAKFTDG
VVVPVNPPSI PGLGTTGGFE FWLQSTGNGS YQQLESRVRA FIAKARQRPE LRGVNSTINT
HSRQLLVDVD RERSESQGVA VSDVYSALQV MFGSLYISQF PKSARLFQVI IQAEPSYRMT
PDDLQNLYVR NKLGDMVPIK SVVTTRYVPG ADIVNRFNNF PAAKIVGDAA PGYSSGQAIA
AMEQVAQEVM GSDNKYEWSG QAYEEKKAGS TAAAVFAFAI LMVFLILAAQ YEKWSLPLGV
IMAVPFALFG ALVGILIRGM ENDVYFQIGL TVLIALAAKN AILIFEFAVE MREKENMGPM
EAALHAAKLR LRPIIMTSLA FILGCVPLAI ASGASSASRR SLGTGVIFGM LGATVIAVFF
IPMFFWGLEA LSERKRGGKQ DSKDAAPNPP EGGHTSPEQG T
//
