ID A0A370U204_9HELO Unreviewed; 1049 AA.
AC A0A370U204;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=BP5553_01785 {ECO:0000313|EMBL:RDL41806.1};
OS Venustampulla echinocandica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Pleuroascaceae; Venustampulla.
OX NCBI_TaxID=2656787 {ECO:0000313|EMBL:RDL41806.1, ECO:0000313|Proteomes:UP000254866};
RN [1] {ECO:0000313|EMBL:RDL41806.1, ECO:0000313|Proteomes:UP000254866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BP 5553 {ECO:0000313|EMBL:RDL41806.1,
RC ECO:0000313|Proteomes:UP000254866};
RX PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA Xiong C., Yue Q., Zhang X.;
RT "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT and Morchella septimelata.";
RL IMA Fungus 9:199-223(2018).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDL41806.1}.
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DR EMBL; NPIC01000001; RDL41806.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A370U204; -.
DR STRING; 2656787.A0A370U204; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000254866; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000254866};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 66..107
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..168
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 169..204
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 746..982
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 439..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 113211 MW; C761E3976AADDCDF CRC64;
MKFIKPAWLT HSGEQKDFEV YSCHVSPDGA RLATAAGDGH VRIWSTEAIL QAGDPNHSKP
KQLCHMSYHS GTIHTVRFSP NGRWLASGAD DKIICIYAID ANPPAHSASF GTNEPAPVEN
WKIVRRLIGH ENDVQDLGWS YDCSILVSVG LDSKIVVWSG HTFEKLKTLS VHQSHVKGIT
FDPANKYFAT ASDDRTIKLF RFTSPLPNAT AYDSINNFVL EHTIVAPFAS SPLTTYFRRC
SWSPDGNHIA AANAVNGPVS SVAIINRGLW DSDINLIGHE GPTEVCTFSP RLFSKQEISP
ETTDNSGYST QALVTVIACA GQDKTLSIWN TSSSRPLVVC QDLAAKSISD LAWTPDGLTI
FASSLDGSII ALEFEKGELG FIAPLSENDK ALQKFGVNRR GVGVVEDVAA LRLEERSKAG
ELRGAEGRMG ALMGDAASNP TPVLNGDGNT NGTSTPMTGV TSTAPAVTNG RSPAQDTPAP
APAVVKDPNA EKLEAMKQRV TITKEGKKRV APLLVSSSGT GLSSLPQSQL MAASSSNAPN
DAPQSILDLS KPYDGLPRGG LAAMLLGNKR KSVALEEDEQ DDQANKRAAA GGANGPIPIM
VNGVNGVEPA IPLLPENGVV PTPEFIRPAV VNPAMSVSQV RLAVPKVRTH ILRSLDRGAL
PSTSGTNGTI NGAEESTKAI DDVVFEAQNP SNPSQMRDPS KISASKRGVN LWQDFLPRAV
ILVTGNKNFW VAACEDGSIY TWTPAGRRIF NALVLEAQPV IIECRGWWLL CITAVGMCYV
WNLKTHGSPH PPVSLAPILD IALHSLGMHT TSAPGVTSAH LNSTGHIIVT LSNGDGYLYS
PSMYVWQRLS EAWWAVGSQY WNSNDSSINT LQSTGVGPDS RRDGVTTSNI SAGIIPHLER
HTTNEVLLKG RAYHLQRLIK SLLSREGFEG FESGVSIAHL ENRVAAALQL GARDEFRIYL
FMYAKRLGAQ GLKTKVEELL KTILGGILQD KTEGEKGEGW LSEDDKLCGW DRKELLKEVV
LILGKFRDLQ RLTVQYSRVL GMDEDENEA
//
