ID   A0A371AXT2_9FIRM        Unreviewed;       436 AA.
AC   A0A371AXT2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   ORFNames=DWV06_05175 {ECO:0000313|EMBL:RDU24367.1};
OS   Anaerosacchariphilus polymeriproducens.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Anaerosacchariphilus.
OX   NCBI_TaxID=1812858 {ECO:0000313|EMBL:RDU24367.1, ECO:0000313|Proteomes:UP000255036};
RN   [1] {ECO:0000313|EMBL:RDU24367.1, ECO:0000313|Proteomes:UP000255036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MCWD5 {ECO:0000313|EMBL:RDU24367.1,
RC   ECO:0000313|Proteomes:UP000255036};
RA   Kim W., Yang S.-H., Oh J., Lee J.-H., Kwon K.K.;
RT   "Anaerosacharophilus polymeroproducens gen. nov. sp. nov., an anaerobic
RT   bacterium isolated from salt field.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDU24367.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QRCT01000013; RDU24367.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A371AXT2; -.
DR   OrthoDB; 9808954at2; -.
DR   Proteomes; UP000255036; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000255036};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        21..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        59..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   436 AA;  48022 MW;  A0ADBDE881D73F54 CRC64;
     MNLENIKNKT VQMILQFSIP SIIAMVLTSL ITIVDGFFIG NYVGKEGIAA VNLGLPIVYV
     YLGFGIMFGV GGIAIAGIAL GAQDIKKSNN VFNQTVISSI IVSVILSIFI CIFMGSIIRA
     VNIDAQVGIY FDKYYSIMIL AYPIMIVNST LGMFIRGEGK PHLFMLINIL TVISNICLDY
     YFIKILRFGI KGIALASLIS LIIGLFSMIL FFLKKSSIYK IRKFQFSKQV LRDTVLNGSS
     EFIGQMSMSI SMFAYNWVIM KNVGVEGVAA FTIVGYIAYL FSMVIVGFGQ GASPLISFSY
     GAKEFELSKT IRKITNIFVF LSGVVVMIIL FIASDWYSNA FVRSESVVAL IRSGLSIFMF
     SFLFSGINTI TSFYFTSIGK AKESAIISLS RGLVVLLICI FTLPTLFGMT GVWLVAPVTE
     AITIVLSIMF IRVNEK
//