ID A0A371BEW6_9SPHN Unreviewed; 1202 AA.
AC A0A371BEW6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=DXH95_01405 {ECO:0000313|EMBL:RDV06124.1};
OS Sphingorhabdus pulchriflava.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingorhabdus.
OX NCBI_TaxID=2292257 {ECO:0000313|EMBL:RDV06124.1, ECO:0000313|Proteomes:UP000263833};
RN [1] {ECO:0000313|Proteomes:UP000263833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GY_G {ECO:0000313|Proteomes:UP000263833};
RA Kim S.-J., Jung G.-Y.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDV06124.1}.
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DR EMBL; QRGP01000001; RDV06124.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A371BEW6; -.
DR OrthoDB; 9816309at2; -.
DR Proteomes; UP000263833; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0008984; F:protein-glutamate methylesterase activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd16434; CheB-CheR_fusion; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00156; REC; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.180; Methylesterase CheB, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR035909; CheB_C.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR022641; CheR_N.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR000673; Sig_transdc_resp-reg_Me-estase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF25; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF01339; CheB_methylest; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF03705; CheR_N; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF13596; PAS_10; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00138; MeTrc; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52738; Methylesterase CheB, C-terminal domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50122; CHEB; 1.
DR PROSITE; PS50123; CHER; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500, ECO:0000256|PROSITE-
KW ProRule:PRU00050}; Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00050};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000263833}.
FT DOMAIN 7..188
FT /note="CheB-type methylesterase"
FT /evidence="ECO:0000259|PROSITE:PS50122"
FT DOMAIN 208..455
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT DOMAIN 846..1059
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1082..1199
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 622..716
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 18
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00050"
FT ACT_SITE 45
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00050"
FT ACT_SITE 137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00050"
FT MOD_RES 1133
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1202 AA; 132024 MW; 273E5818F9E682DF CRC64;
MPDMQYPVEF PVVGVGASAG GLEAFSGLLE AISDTSGKAF IFVQHLDPKH ESLLVDLLGT
HTSLQIKQAT EGLRVDPNHI YIIPPSAYLA VRKGVLHITR PSSKHGARLP FDFLLKSLAE
NYGPRAMAVV LSGTGADGSE GISAIKNKGG IVYAQDPSEA EYGGMPECAI DTGCVDATAT
VAAIGSLLSM RTANPSAQSD QRDAQTAIIE LLRATTPHDF RLYKPGTLQR RIERRMLLAS
ISPEKMADYL ERLQQDHEER DLLAKDLLIN VTSFFRDPKV FETLGTTFLP DLIAKHPANE
PLRIWVAGCS TGEEAYSFAI VFREVLTALN SRIKLQVFAS DVDADAVGFA REGIYPATIA
ADVSPERLAR FFIADGQGYR VTRELRSTVV FSVQDILSDP PFSRLDLVSC RNLLIYLGPE
AQAKVIAILH FALRNDGILL LGNAETIANV EGRFEILSKD KRIYRHLGRT GLAGVGFHMN
ADNLLRLPPG IGQRSVGKRH ASLAEFCEQQ VLDRYAPAAV LINRNQECLY TVGPVERYLQ
IAAGHPTHDL LAMVAPTLRA HLRTALLAVN PASPSVVKPG GKIDSAPFNI EVQSVDYEGE
ELRLVCFLDA PMRNSKVAPS PVTTESERIN ELEKELQVTR SELQVAINNL EMSVEEQHAV
NEEALSVNEE FQSTNEELLT SKEELQSLNE ELTALNSQLQ ESLERQRTTS NDLQNVLYST
DVATLFLDMQ FNIRFFTPAT RALFSIIASD IGRPLSDLNS LASDTALLED ARTVLESLDP
IDREIQVGGD IWFVRRIMPY RTDNGVEGVV ITFTDISERR HAAKIVDEAK KAAERATVAK
SRFLAVASHD LRQPLQTLSL LQGLLAKSVE GEKPQRLVAR LDETLGAMTG MINTLLDINQ
IEAGTITTQI SRFPISDLLD QLRDEFSYHA KAKKLELRVV QCSVVVQTDR RLLEQMLRNL
LSNALKYTER GRILMGCRRL ADGISIEILD AGIGIAPDQI HAIFDEYHQV DNAARERSRG
LGLGLSIVQR LGKLLGHPVR VRSVLGKGSA FAVEVKLPLN ELVDGPAPAT ASSKANTFRT
ANILIVEDDP EVRLLLEQLL SDEGHITATA VDGKASLKLV ESGKMQPDLV LADYNLPKGM
NGLQLATKLR TMINTELPVI ILTGDILTET MREVAAQNCM QLNKPVKVGE LSKTIQKLLA
RP
//
