ID   A0A371DXT9_9APHY        Unreviewed;       962 AA.
AC   A0A371DXT9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Dbl homology domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=OH76DRAFT_1476727 {ECO:0000313|EMBL:RDX57314.1};
OS   Polyporus brumalis.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Polyporaceae; Polyporus.
OX   NCBI_TaxID=139420 {ECO:0000313|EMBL:RDX57314.1, ECO:0000313|Proteomes:UP000256964};
RN   [1] {ECO:0000313|EMBL:RDX57314.1, ECO:0000313|Proteomes:UP000256964}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRFM 1820 {ECO:0000313|EMBL:RDX57314.1,
RC   ECO:0000313|Proteomes:UP000256964};
RX   PubMed=30061923; DOI=10.1186/s13068-018-1198-5;
RA   Miyauchi S., Rancon A., Drula E., Hage H., Chaduli D., Favel A., Grisel S.,
RA   Henrissat B., Herpoel-Gimbert I., Ruiz-Duenas F.J., Chevret D., Hainaut M.,
RA   Lin J., Wang M., Pangilinan J., Lipzen A., Lesage-Meessen L., Navarro D.,
RA   Riley R., Grigoriev I.V., Zhou S., Raouche S., Rosso M.N.;
RT   "Integrative visual omics of the white-rot fungus Polyporus brumalis
RT   exposes the biotechnological potential of its oxidative enzymes for
RT   delignifying raw plant biomass.";
RL   Biotechnol. Biofuels 11:201-201(2018).
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DR   EMBL; KZ857379; RDX57314.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A371DXT9; -.
DR   STRING; 139420.A0A371DXT9; -.
DR   Proteomes; UP000256964; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000256964}.
FT   DOMAIN          202..391
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          426..561
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          602..912
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          47..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   962 AA;  109352 MW;  97094AE5E1653CAA CRC64;
     MAHRSRPHVT IPAGAAPPLN PSPSAHDQSL SPINLWADRR NPVYTVHTPS SPSLLSSSHP
     GPRISLDVPG RPPSRAASAY EYETSRLSFP EPQLHRSSSQ RTPYRSTSTN FTHRTSRSES
     VLTPDGLLTP TQYSISGESS RPPSFFENTP ESISRDLSTE LTELSNVEEA LRKFQAGELP
     DAEWYRLVSP SVREVLDKKE VQRQSILFEI IKSEKDYVAD LELVKEVFID PLMNTLAVPS
     SRVKNFIREV FFNFDEILQH HQKMLTALFA RQREQHPWVM TVADIILDNC LEFLAGYEEY
     IKHYPIAEMR HRSEMRRNTK YQYLVQQCSL DPRVRKRDII TFISRPVTRL PRLQLLLDNA
     RKFTEPESQD AEDIPVILGI LNEFIRSTQP GIEAAEEKVK FWSLCESLVY QKGEIIDLDL
     YDDTRSLQYQ GRLSRKYKSE MNYHWADLHV ALLDNYLLLL KPDVRSNDGR ANPPTRHHVV
     SRPIPIDYLR LGMFDGPPEN RKEKAEDGGL GLLDRVRPKY RQMFPFTIYH ASSKMNRRYT
     LYAQSEQVRD RWLTAFNTAL DIRRYRQEGN MFFVTHVIND GFFKQASSYT SGNFNGAGAH
     FTGRINAAIK FSSTAHKFVA VASSSGVFVA QKGEPAFRKV LSVYNPTCLV ALPDVNKFFV
     LHDQGLYAYS LDLVARATLG ISSTENAEAS KERIAGDVLF FRAGRVGSRP MVLYVAKSFL
     QYNLYALEVV NSSDLHINPR RNTNGLFSFR AFGEPVSIPK DTLDIIMFRQ RIVICSDKGL
     SLVDPTNLSL SAKSTLIPDF SDADFNNNLP MMTLKSRCAS SKPLGIVRCD SSDELLVIYD
     ELGCYTNKYG VPSRSSGYLR WETKATSYSW RGEHILLFSP EFIEIRTVQT GKLVQVIEGA
     DMRRVDVGLL TSDKDLTTLV AMKGREEQGL VVDTLQELVE TTEIRTTRSS EVPGMFDDFE
     VM
//