ID A0A371E9X5_MUCPR Unreviewed; 1646 AA.
AC A0A371E9X5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DExH-box ATP-dependent RNA helicase DExH6 {ECO:0000313|EMBL:RDX62838.1};
DE Flags: Fragment;
GN Name=HVT1 {ECO:0000313|EMBL:RDX62838.1};
GN ORFNames=CR513_58790 {ECO:0000313|EMBL:RDX62838.1};
OS Mucuna pruriens (Velvet bean) (Dolichos pruriens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Mucuna.
OX NCBI_TaxID=157652 {ECO:0000313|EMBL:RDX62838.1, ECO:0000313|Proteomes:UP000257109};
RN [1] {ECO:0000313|EMBL:RDX62838.1, ECO:0000313|Proteomes:UP000257109}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jos {ECO:0000313|Proteomes:UP000257109};
RC TISSUE=Seed {ECO:0000313|EMBL:RDX62838.1};
RA Nnadi N.E., Vos R., Hasami M.H., Devisetty U.K., Aguiy J.C.;
RT "Draft genome of Mucuna pruriens seed.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDX62838.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QJKJ01015245; RDX62838.1; -; Genomic_DNA.
DR STRING; 157652.A0A371E9X5; -.
DR Proteomes; UP000257109; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd06222; RNase_H_like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR044730; RNase_H-like_dom_plant.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:RDX62838.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 440..616
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 775..949
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 154..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RDX62838.1"
FT NON_TER 1646
FT /evidence="ECO:0000313|EMBL:RDX62838.1"
SQ SEQUENCE 1646 AA; 182644 MW; ADE1B3E45CB1B1D7 CRC64;
MRNNLAMLGT STPLGIAHIA PELHESRFAG ELYDSGFVQV EHWAGRVMSD PILKTLRKTV
CWNVVGSCFV SVLQWMLLYN FETRLSHEEC GFVNYFCKKE ELYSRSWNGT VAKAMDGIKP
RISIRKTKKD VDNTTLIENL PNVTCSAESD QVDMLKRSQE KEEPESPQHP KKSQEKEEPE
SPQHPNFIVM EPKSVQISRT LEIFLASEDE GLTHLQCPVI CLFVFFGVYN FENALSPKDC
ALVEQLSQKK GLSCTFSGGI RKKISVHKTK KEVDTTKVLG SLLHVTFSEE SNQNNKEPEP
PQHQNPIVDE LTTIQISQIL DNFLASKDEV YNFEANLSPE ECVAVHQLSQ KMGFRVLGGL
LMHYPPGDEE LWGEMIGGYS DTTDRMEQKE DDIFSRPYMS KVEITKQLED LSARMKNSCH
LKLIQKRSKL PIASMKDTII STVESHQVVI ICGEAGCGKT TQVPQYILDH MWGKGEVCKI
VCTQPHSISA TSVSERISSE RGETIGNSVG YKIRFESKGG RQSSIVLCTT GVLLKLLVST
GSHFRKTQSE KDDISSISHI IVDEVHGRDR YSDLMLATLR EMLPSNPHLR LILISACFDA
ARFSQYFGIC PIIHVPGFKY PVKTYYLEDV PIVKCGADNQ LDDNHELSEE ERLSLDEAID
LAWSNDEWCS LLELICSKAS PEVFDYQHSL TGLNPLMVFA GKGKVGDMCM LLSLGANCYL
RAKDGTTALE IAEKENQQVA VELLQKHMDK DFSNKGTDLL DKYLATANRK VDVVLIEQLI
RKICSDSKDG GIIVFLPGWD EIIRLRERLL ASHFFNRGSK FMVISLHSMV PAIEQKELFM
PASHGCRKIV LSTSIAETAV TVDDIVYVID TGLVEEKIYD SYNNVLTLQS SWISKESAEL
RKGCASRCQP GINYCLYSKV QAASLPDFQV PEIKRMPIED LCLQVKLFDP SCKIEEFLNR
MLNPPGVGSI RNAVGVLQEI GALSVDEKLT QLGEKLGSLP VHPSTSRMLL FSILMNCLDP
ALTLACASDF KDPFVLPILP DEKERAAAAR SELASLYGGC GDQFSIIAAF ECWHNSKEMG
LESRFCSQYF ICQSTMNMLS GMRKNLAAEL YRNGLIHGDV SSYSSNAHDP GILQAVVVAG
MHPMVGKLFV PYKSGNRFFV KTKSGDVCLN SHSVNSKLPS QKSFDCSLVV YDEITSSDWG
MCTRNCTVVE ILPLFLFSKE IAVAPAKDCT EGDEFSSSPA NKVRVTVNRW LDFESTALDA
SQMNYLRKRL SAAISYKVTH STDILPPVLQ AAVDALACIL SCRGLSCMPQ TSGCANTLTT
INATNPKELQ TELINHDVCH TNPEPEVIEI PSNQTSQNAP IGLACSTPTE QTDKTAEGFC
TGHITHSDMP SSGTSISTSN EAENPSDLTS WNTATDSIQS AHINDDATMI SVTPSKHRYL
KKQSASKVWW TCPEVGWMKV NVDGSFRRYL NLSSGAGVFR DSTGSWCFGF ALNLGLLSYG
SSDPAKATVS HLITMAELWS IFTALKLGRE KGISQLWIET DSTIAVACVL NRREGSVYEP
LVQSIFELMA EYCMVRISHC YREGNQVADY LASYAHDLEV GLHILDVPPP GCIQFLADDS
AGVYKLRDAR ICDEFGFGGI VPPSNS
//
