ID A0A371EQ55_MUCPR Unreviewed; 681 AA.
AC A0A371EQ55;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
DE Flags: Fragment;
GN Name=PI4KA1 {ECO:0000313|EMBL:RDX68195.1};
GN ORFNames=CR513_52835 {ECO:0000313|EMBL:RDX68195.1};
OS Mucuna pruriens (Velvet bean) (Dolichos pruriens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Mucuna.
OX NCBI_TaxID=157652 {ECO:0000313|EMBL:RDX68195.1, ECO:0000313|Proteomes:UP000257109};
RN [1] {ECO:0000313|EMBL:RDX68195.1, ECO:0000313|Proteomes:UP000257109}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jos {ECO:0000313|Proteomes:UP000257109};
RC TISSUE=Seed {ECO:0000313|EMBL:RDX68195.1};
RA Nnadi N.E., Vos R., Hasami M.H., Devisetty U.K., Aguiy J.C.;
RT "Draft genome of Mucuna pruriens seed.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDX68195.1}.
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DR EMBL; QJKJ01012646; RDX68195.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A371EQ55; -.
DR STRING; 157652.A0A371EQ55; -.
DR Proteomes; UP000257109; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RDX68195.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 121..298
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 372..650
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RDX68195.1"
FT NON_TER 681
FT /evidence="ECO:0000313|EMBL:RDX68195.1"
SQ SEQUENCE 681 AA; 76605 MW; 6CD678814D4E4A71 CRC64;
ASLGWFAFEP EWYDTNYTNF AQCEAQSVSL FVQYLSNMKV ESIQFGSKGN GQENGNPSAD
VSEHYHPVWG QMENYAVGRE KRRQLLLMLC QHEADRLEVW AQPTNTKENI SRPKISADKW
IEYTRTSFSV DPRIALSLSS RFPTNTFVKT EVTQLVQANI VDVRNIPEAL PYFITPKAVD
DNSVLLQQLP HWAPCSITQA LEFLSPAYKG HPRVMAYVLR VLESYPPERV TFFMPQLVQS
LRHDDGKLVE GYLLRAAQRS DIFSHILIWH LQGETVPEPG KDPSSGKNGS FLELLPAVRQ
LIIDGFSPKA LDIFKREFDF FDKVTSISGV LFPLPKEERR AGIRRELEKI EMDGEDLYLP
TAPNKLVTGI RVDSGIPLQS AAKVPIMITF NVVDRDGDKN DVKPQACIFK VGDDCRQDVL
ALQVIALLRD IFEAVGINLY LFPYGVLPTG PERGIIEVVP NTRSRSQMGE TTDGGLFEIF
QQDFGPVGSA SFEAARQNFI VSSAGYAVAS LLLQPKDRHN GNLLFDNVGR LVHIDFGFIL
ETSPGGNMRF ESAHFKLSHE MTQLLDPSGV MKSDTWNQFL SLCVKGYLAA RRRMEGIITT
VALMLDSGLP CFSRGDPIGN LRKRFHPEMS EREAANFMTH VCKDAYNKWT TAGYDLIQYL
QQGIEKNFHG FSIEEGIVVN G
//
