ID   A0A371FD18_MUCPR        Unreviewed;       788 AA.
AC   A0A371FD18;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Cation/H(+) antiporter 4 {ECO:0000313|EMBL:RDX76192.1};
DE   Flags: Fragment;
GN   Name=CHX4 {ECO:0000313|EMBL:RDX76192.1};
GN   ORFNames=CR513_43843 {ECO:0000313|EMBL:RDX76192.1};
OS   Mucuna pruriens (Velvet bean) (Dolichos pruriens).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Mucuna.
OX   NCBI_TaxID=157652 {ECO:0000313|EMBL:RDX76192.1, ECO:0000313|Proteomes:UP000257109};
RN   [1] {ECO:0000313|EMBL:RDX76192.1, ECO:0000313|Proteomes:UP000257109}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Jos {ECO:0000313|Proteomes:UP000257109};
RC   TISSUE=Seed {ECO:0000313|EMBL:RDX76192.1};
RA   Nnadi N.E., Vos R., Hasami M.H., Devisetty U.K., Aguiy J.C.;
RT   "Draft genome of Mucuna pruriens seed.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC       {ECO:0000256|ARBA:ARBA00038341}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDX76192.1}.
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DR   EMBL; QJKJ01009598; RDX76192.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A371FD18; -.
DR   Proteomes; UP000257109; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR   PANTHER; PTHR32468:SF97; CATION_H+ EXCHANGER 3; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        117..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        148..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        217..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        334..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        430..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          62..449
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   NON_TER         788
FT                   /evidence="ECO:0000313|EMBL:RDX76192.1"
SQ   SEQUENCE   788 AA;  88613 MW;  38DF53FED40B2A1E CRC64;
     MDINTNDTLF ASINLVDASH HRVKYDVCLH TPPHIVSDGI WGGHSMEGSP LRSSFPIFLL
     QVIVIYTITR ALHFPVKKLG LPTIISQIMA GIILGPSLKI LEKDKMMLFP YGSQDTLATI
     TSLGYVLFVF ENGVKMDFSM ITRTGKKIWV IALVGLALPL LVCYPTLDNL STALTQSIGD
     TNRSVVVMLV TQNITSFAVI SSILNDLQIL NSELGRLTLS CALVGDILSN ILIFSTTVFG
     EEHNIKILSI NLVSLFVLII IIFFIYRPIM FWVIEHTPER QEVKDIYINI IIGILFTLGW
     CSMLLKQEFI LLPFIFGLAT PEGPPLGSSL VKRIHVFGIE FLLPIFLTTC AMKINFGLLE
     FSSFTIIATT FVVLYGHLLK MIAYVASSRY LINLPLRDAV SFALLLNCKG VVEVSMYSSA
     LDKNDLLAEV YTVIITIIMI TSSIAHLLVK RLYDPSRKYV GYQRRNIFNL KPNSGLRIQV
     CIHKQHNTIP MIRVLDLCNP TPEDPITVDV LHLIELVGRS SPIFISHRMK KRVPSHMQSS
     YSENIILSFK LYEDEKQDAT IINPYTAISP LTFMHEDVCC LALDKVTSII ILPFHRKWSI
     EGKIEYEDKT IRSLNCKVME KAPCSVGILV SRYVHQRDSP LRLAMIFLGG KDDREALCLA
     NRAIKDSSVN LVVYHITTNT KNEIQDLDIM LDLAMLKDAK EEYSSLKNVI YKEITVEGGA
     QIASILRQMI DEHDFFIVGR RHGIDCPQTK GLQEWSEFTE LGLIGDFLSS TDLDCKSSVL
     VVQQQQLS
//