ID A0A371JNG7_9FLAO Unreviewed; 381 AA.
AC A0A371JNG7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase {ECO:0000256|ARBA:ARBA00013253};
DE EC=2.7.6.3 {ECO:0000256|ARBA:ARBA00013253};
GN Name=folK {ECO:0000313|EMBL:RDY58786.1};
GN ORFNames=DX873_14050 {ECO:0000313|EMBL:RDY58786.1};
OS Allomuricauda nanhaiensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Allomuricauda.
OX NCBI_TaxID=2292706 {ECO:0000313|EMBL:RDY58786.1, ECO:0000313|Proteomes:UP000261828};
RN [1] {ECO:0000313|EMBL:RDY58786.1, ECO:0000313|Proteomes:UP000261828}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM1704 {ECO:0000313|EMBL:RDY58786.1,
RC ECO:0000313|Proteomes:UP000261828};
RA Dang Y.;
RT "Muricauda nanhaiensis sp. nov., isolated from seawater of the South China
RT Sea.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC dihydroneopterin triphosphate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00005051}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDY58786.1}.
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DR EMBL; QTJX01000003; RDY58786.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A371JNG7; -.
DR OrthoDB; 9776634at2; -.
DR UniPathway; UPA00077; UER00155.
DR Proteomes; UP000261828; Unassembled WGS sequence.
DR GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01673; dNK; 1.
DR CDD; cd00483; HPPK; 1.
DR Gene3D; 3.30.70.560; 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR000550; Hppk.
DR InterPro; IPR035907; Hppk_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01498; folK; 1.
DR PANTHER; PTHR43071; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR43071:SF1; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF01712; dNK; 1.
DR Pfam; PF01288; HPPK; 1.
DR SUPFAM; SSF55083; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RDY58786.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261828};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RDY58786.1}.
FT DOMAIN 8..136
FT /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase"
FT /evidence="ECO:0000259|Pfam:PF01288"
FT DOMAIN 181..373
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
SQ SEQUENCE 381 AA; 44517 MW; 69D5CAEB0C2C7659 CRC64;
MNPKKQVYLS LGSNMGNRYV QLQKAIFHLQ SKAGEITAVS SIYENPAVGF EGDDFLNACL
GIATELSPHE LLKVILEIEK DFGRERSLSG GYSSRTLDLD ILFYENEVIH TKDLVVPHPH
IQDRNFVLKP LADIAPQYYH PVFNKDIRNL LQECKDRGKL KKTKYKLFKS RLELFSQLQF
IAIEGNIGAG KSTLSKMIAD DFNAKLILER FADNPFLPKF YKDQARYSFP LEMSFLADRY
QQFSDDTSQF DLFKNFMVSD YDIFKSLIFA QITLQADEFE LYRKVFNFMY KEVKKPEIYL
YLYQNTERLL ENIKKRGRDY EQNISADYLE KIHRGYMDFI KGHPGQNSMV LDLSELDFVN
NPSDYEYILQ ALEHRILSSI F
//
