ID A0A371NX81_9MICO Unreviewed; 1054 AA.
AC A0A371NX81;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=MFS transporter {ECO:0000313|EMBL:REJ07803.1};
GN ORFNames=DY023_02210 {ECO:0000313|EMBL:REJ07803.1};
OS Microbacterium bovistercoris.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=2293570 {ECO:0000313|EMBL:REJ07803.1, ECO:0000313|Proteomes:UP000262172};
RN [1] {ECO:0000313|EMBL:REJ07803.1, ECO:0000313|Proteomes:UP000262172}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEAU-LLE {ECO:0000313|EMBL:REJ07803.1,
RC ECO:0000313|Proteomes:UP000262172};
RA Ling L.;
RT "Isolation, diversity and antifungal activity of Actinobacteria from cow
RT dung.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000256|ARBA:ARBA00008537}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REJ07803.1}.
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DR EMBL; QUAB01000014; REJ07803.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A371NX81; -.
DR OrthoDB; 102502at2; -.
DR Proteomes; UP000262172; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd17321; MFS_MMR_MDR_like; 1.
DR CDD; cd07205; Pat_PNPLA6_PNPLA7_NTE1_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00711; efflux_EmrB; 1.
DR PANTHER; PTHR42718:SF47; DRUG EFFLUX PUMP JEFA; 1.
DR PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000262172};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 29..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..474
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 511..610
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 795..955
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 1054 AA; 110409 MW; 76451E67930FF97C CRC64;
MALRTPEAGV AGRTRESALR RGRIPGRTVL LVASFGAVLA FLDATIVNIA FPSIRESFPD
DSIGTISWVL NAFNIVFAAF MIVFGRLGDV VGRKRLYLIG IGLFTIASVI CALAPSVGML
VAGRILQALG AAMIVPASLA LVIEGFPAGK RARAVGLWAA AAAVAAGLGP PLGGLVVEAG
GWTWAFWINL PLGVIAWWLG RRQLVNSRAP GRRRMPDLRG ALLLAASLAL ITLAIIKASE
WGAASPLLWT VVVAAVLLLA GFVLSSMKHP VPVLDLAMMR DRTFLVANIA TLVAGVGFFG
YMLTNVLWLQ YVWQYTVLEA GLALIPGALV AAVTAGLLEP VAERFGYRWI IAAGFVVWAL
GYAWYVGVVG TTPDFWGQWL PGQVISGIGV GATLPLLASS TLASQPGGKY ATASAVISSA
RQIGGTIGVA LLVVILGAPT PLTVVQDLRD GWTMCIVSFA AGAVITLFLG RAGNSAEGRD
EEPIVESDLR EPDAGRSVLL RRELPPVEES LFGRLPAATR ERIVGTAPRR TVPAGDWVLR
QGDAAESMFV LISGRAEVVI GEQVVREVGP GAVLGELALF TGDLRSASVR ARRDCQVLEV
SRALLDEAIG EDPVALSALV TALAHQLAEA SPPATRVASR PSLVAVLAAA PGAPVEAVAA
VLHRGLSEHL RVALLHGPHT PEQVDRAEAE NQMVVLVAVG ADEAWAARCA READTVVLVG
VSGDAPAGTT PPMAGRAELV LVGESPSRAM RQTWLDAVDP WRISELSFAD AGTPGAVPSS
LRGLVDRLAG RSIALVLGGG GARALTHIGV LLELEEAGLR IDRVAGASMG SVIAGYYATG
VTAADVGDVA YREFVREDIL GDYGLPRTSL ARGSRVQKAL ARTFGDLRIE ELPRGFRCVS
TDLLARSTVV HRTGHLGDAI KASSRLPVLF SPIPSDGRLL VDGGVLDNLP VDTVTERSEG
PIIAVNVSMS GGRRRAPGEA PRPVRVPPLG ETMLRTLMIG GGGAAEAQRL GAWVITPPSM
GVGLLEFHQY DRMVEAGRAA ARTLLDQTGD IFAA
//
