ID   A0A371QKC9_9BACT        Unreviewed;       391 AA.
AC   A0A371QKC9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:REL29115.1};
GN   ORFNames=DYD21_14765 {ECO:0000313|EMBL:REL29115.1};
OS   Rhodohalobacter sp. SW132.
OC   Bacteria; Balneolota; Balneolia; Balneolales; Balneolaceae;
OC   Rhodohalobacter.
OX   NCBI_TaxID=2293433 {ECO:0000313|EMBL:REL29115.1, ECO:0000313|Proteomes:UP000263328};
RN   [1] {ECO:0000313|EMBL:REL29115.1, ECO:0000313|Proteomes:UP000263328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SW132 {ECO:0000313|EMBL:REL29115.1,
RC   ECO:0000313|Proteomes:UP000263328};
RA   Song L.;
RT   "Rhodohalobacter alkaliphilus sp. nov.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:REL29115.1}.
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DR   EMBL; QUOK01000008; REL29115.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A371QKC9; -.
DR   OrthoDB; 9787435at2; -.
DR   Proteomes; UP000263328; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000263328};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          26..149
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          196..271
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   391 AA;  42181 MW;  AB1A5AB1E47E3710 CRC64;
     MKALCWHGKN DVRIDNVPDP ELHQAGDVIL KVTSTAICGS DLHLLSGLMP TMEEGDILGH
     EFMGEVVDVG KEVTTLKKGD RVVVPFTISC GLCHFCGESL FSLCDNSNPN ADQAIEVMGH
     SPAGLFGFSH MLGGFSGGQA EYVRVPYADI GPVKVPDSLS DDKVLFLSDI FPTGYMAAEN
     ADITPGDIVA VWGCGPVGQF AIKSAWMLGA ERVIAIDRVP ERLKMAKEMC DAEIIHSTDP
     SEIYETLMAM TDGRGPDCCI DAVGAEAHGG STIRSIKDKA MGKAHLDVAK PYVLQQMIQC
     CKKGGTISIP GVYVGPVNAF PIGSAMNKAL TFKMGQTHVQ HYLKPLLEKI ANDEIDPSFI
     ITHQLKLEDA PEAYKLFRDK KDSCVKVVLT P
//