ID   A0A372G120_9ACTN        Unreviewed;       309 AA.
AC   A0A372G120;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=5'-3' exonuclease {ECO:0000313|EMBL:RFS46732.1};
GN   ORFNames=D0Q02_09890 {ECO:0000313|EMBL:RFS46732.1};
OS   Micromonospora craniellae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=2294034 {ECO:0000313|EMBL:RFS46732.1, ECO:0000313|Proteomes:UP000262621};
RN   [1] {ECO:0000313|EMBL:RFS46732.1, ECO:0000313|Proteomes:UP000262621}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LHW63014 {ECO:0000313|EMBL:RFS46732.1,
RC   ECO:0000313|Proteomes:UP000262621};
RA   Li L., Lin H.W.;
RT   "Verrucosispora craniellae sp. nov., isolated from a marine sponge in the
RT   South China Sea.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFS46732.1}.
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DR   EMBL; QVFU01000007; RFS46732.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A372G120; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000262621; Unassembled WGS sequence.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR   PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000313|EMBL:RFS46732.1};
KW   Hydrolase {ECO:0000313|EMBL:RFS46732.1};
KW   Nuclease {ECO:0000313|EMBL:RFS46732.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000262621}.
FT   DOMAIN          5..276
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
SQ   SEQUENCE   309 AA;  32990 MW;  3A43F04AA2EC02ED CRC64;
     MAQQTPIMLV DAPSLYFRAY FGIPESAART ADGQPVNAVR GFLDMLAQLV RTRRPGRMVC
     AMDHDWRPDW RVALLPSYKA HRVAPEGGEV VPDTLSPQVP MILDVLDALG VTVVGAAGYE
     ADDVLGTLSV TQPGPVEVVS GDRDLFQLVD DARGVRLLYI GRGVAKLDDC DDTAVRSRYG
     VAADRYADFA ALRGDPSDGL PGVAGVGEKT AARLIERYGD IDGILAALDD PASGFAPGLR
     TKLDAARDYL AVAPKVVRVA LDVPLPPLPT ELPAAPADPE RLVELAERWN LAGSTRRLVD
     ALATRTTTA
//