ID   A0A372G2H1_9ACTN        Unreviewed;      1205 AA.
AC   A0A372G2H1;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Adenylate/guanylate cyclase domain-containing protein {ECO:0000313|EMBL:RFS47084.1};
GN   ORFNames=D0Q02_07985 {ECO:0000313|EMBL:RFS47084.1};
OS   Micromonospora craniellae.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=2294034 {ECO:0000313|EMBL:RFS47084.1, ECO:0000313|Proteomes:UP000262621};
RN   [1] {ECO:0000313|EMBL:RFS47084.1, ECO:0000313|Proteomes:UP000262621}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LHW63014 {ECO:0000313|EMBL:RFS47084.1,
RC   ECO:0000313|Proteomes:UP000262621};
RA   Li L., Lin H.W.;
RT   "Verrucosispora craniellae sp. nov., isolated from a marine sponge in the
RT   South China Sea.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFS47084.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QVFU01000005; RFS47084.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A372G2H1; -.
DR   OrthoDB; 5476461at2; -.
DR   Proteomes; UP000262621; Unassembled WGS sequence.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000262621}.
FT   DOMAIN          39..167
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1205 AA;  126272 MW;  3ECFB82CBBF24624 CRC64;
     MTCPVCGTVA VPGARFCHNC GAALPAAATL PATERRVVTV LFGDLSDFTS WSEDLDPERV
     GAVTDRVLAA LAGAVKTFGG HVDKLTGDGI MAVFGAPVAH EDDAERAVRA ALSMQRAVRR
     VLDDERGGGA PLGLRVGLNT GDVIAGIQAA IEYTVIGDTV NTAARLADAA AVGAVYAGAR
     TAAATRHVAS WRALRPLRLK GKREPVEAYE LLGLLDAPGT RSGLGDEAPF VGRETEIGRV
     AGRLAEVIDR GEPRVLLMTA EAGIGKSRFA AEVERLAAGY DVGAGRYAAH TGARVLSVRC
     AAFGERRRLA PLADLVRAAT GLPNDTATAV TRAAVEERLR RLGQRLSRSR TEPAPVAVDQ
     LLALLGYAEL PAAAHTDQSE WTGTQPPPDA EAVPNAVAAL LSALAEEAPL MVVVDDLHDA
     TAETIGALEV TLSRLDGPVL VLLLGRPELV RTAGTLARVA DAEVQPLPPL RGADASRLLT
     SYLGGGRLPQ ADADRLLATA QGNPFYLAEL VTLLMERGAL TAGARNDWRL APGSLGSRLL
     SRDLAAVLAA RIDALPAEAR SVLRDAAVVG DTVPDGALEA LREQRAGRDG RPAAVVALEL
     DRAVEELLQR RMLHRTRTGY AFATPLMREA AYAGVSKAEL AERHAALARW ANPAGSVTSG
     LGGPDLVPTG ATGGPSGFTE AARDDFVAQH VERATALADA VTLRPDAPAR AVAPLGVAAL
     GRATRRALHE GEPALAVEYA ERAAELARVD GVPAQDRVVH ARALLQVGRV ADALASAEKI
     AANAGDQATT RISALLLAGQ AQQAMGDLRR AETCWREALQ VATEADLPGL RASAMRRLGM
     ADFLAGRLGE ASSRLAAAYQ VSLAVQDRRG QAWSLQNLAW VTTTRGDFAG TDAVLGRAAR
     LFAELKDPYG RAWLRGTTAF ARLLAGRLRE ARRLARIFLP FGERVGEAWA VGTLRAVDAY
     ANAELGELLD ADREARRAYR EFAAASDEWG QGFALVVRGV VARGLGEPEH AADLLTGALE
     YAGRTAHPLL TGMAGTLRGF VALDMGDVAG AERYARAVLT SVEPHNPQAP AQVGPRVLLA
     TARLAAGDSG TAVGLLAPVA TAAATSPSLL FSRRQSMARY ASALLAHGQC EQALDWARRA
     AAAPAEDVRS QVVTARVRAE ALAACGRPAE ALTSAEEAVR LSYATEQRSE RVDAEALYTR
     LRDAG
//