ID A0A372GC83_9ACTN Unreviewed; 1831 AA.
AC A0A372GC83;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=ATP-grasp domain-containing protein {ECO:0000313|EMBL:RFS83004.1};
GN ORFNames=D0T12_22670 {ECO:0000313|EMBL:RFS83004.1};
OS Actinomadura spongiicola.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=2303421 {ECO:0000313|EMBL:RFS83004.1, ECO:0000313|Proteomes:UP000262882};
RN [1] {ECO:0000313|EMBL:RFS83004.1, ECO:0000313|Proteomes:UP000262882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW52907 {ECO:0000313|EMBL:RFS83004.1,
RC ECO:0000313|Proteomes:UP000262882};
RA Li L., Lin H.W.;
RT "Actinomadura spongicola sp. nov., isolated from marine sponge Leucetta
RT chagosensis.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFS83004.1}.
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DR EMBL; QVNQ01000007; RFS83004.1; -; Genomic_DNA.
DR OrthoDB; 5166719at2; -.
DR Proteomes; UP000262882; Unassembled WGS sequence.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866:SF126; BIOTIN CARBOXYLASE; 1.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000262882}.
FT DOMAIN 1..452
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 125..323
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 576..659
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1552..1828
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 1831 AA; 197932 MW; 1DDD02DE9BBD0B60 CRC64;
MFSRVAIVNR GEAAMRLIHA VRDIAAETGT RIETVALHTD VDRTATFVRE ADLSYDLGPA
SARPYLDLKV LERALVESGA DAAWVGWGFV AEDPAFAELC DRIGVTFVGP SADAMRKLGD
KIGAKLIAEE VGVPVAPWSR GAVETLEAAL RSAAEVGYPL MLKATAGGGG RGIRVISNEA
ELIDAYERTS QEAARAFGSG VVFLERLVTG ARHVEVQVIA DGQGTAWALG VRDCSVQRRN
QKVIEESSSP VLSAEQAAEL KASAERLAVA VGYRGAATVE FLYHPGDRLF AFLEVNTRLQ
VEHPITEATT GFDLVRAQLW VASGGRLDGA PPAERGHAIE ARLNAEDPDR DFAPSPGRIA
RLVLPAGPGV RVDTGVREGD TIPADFDSMI AKIIAVGRDR AEALARLRRA MAQTTVVIEG
GATNKSFVLD LLDRPEVIDA SADTGWIDRV RAAGELVSHR HSAVALAAAA IDAYEEEERA
ERQRLLATAF GGRPQVRHES GRPLDLKLRG VGYRLRVARV GAHRFRVGVE VVGGDEETAR
TAVVELDRFD RHTGQIVVNG TRYRLLTATH GPVHLVEVDG VTHRVSRDEG GVVRSPAPAL
VVATPLKVGA EVEAGAPVLV LESMKMETVL RAPFKARLKE CVVSVGAQVE TGAALLRLEP
LADDAEDAED EATGTVELDL PDGPGTVSAW ERAARCQEEL RSLLLGFDVD PHDEGRVLGD
YLAAREESGG DRTLAGELEL VEVFTDVAEL GRNRPAGIEV GGAGGGEGSH VHSDREYFHT
YLKSLDVDRA GLPEAFQAKL TKALGHYGVT GLDRSPELET AVFRLFLAQQ RTSADVRVVA
TLLRTWLREP PPDQATHEPI GLALERLVAA TQVRFPAVAD LARGVVFAWF AQPLLRRNRA
RVYADVRRHL RYLDAHPDAP DRADRIAEMV RSTEPLVRLL GRRLVRHDRD NTVMLEVLTR
RYYGNKGLTG VHTREVGGCE FVVAERADSC VVSAAVGFDA FGGALRGLAE LTGGADAPGA
DTDADIYLAW ENQPEDFDAM AAALHEVVNA HPLPERVRRL TATVAGSGGA VMHHHFTFRP
EAGGMVEERL IRGLHPYIAQ RMQMERWSGF DLTRLPSADE EVYLFRGVAR ENPSDERLVA
FAQVRNLTEL RDHEGRLLAL PTAEYTVAAC LDSIRRAQAL RSSKKRFNTN RVVVYVWPPS
HLTRAELEMI AGRVLPTTVG AGLEEILFIA RQRDPRTGGL DKIAVRIAFD VTGGAELTVG
APSDEPVEPV DAYRQKVLGA SSRNTVYPYE LTGLLGDFVE HDLDDANALV PVDRPKGRNT
AAMVAGVVRT PTARYPEGVT RVVLLGDPTK SLGALSEPEC RRVIAALDLA ERMRVPVEWY
ALSSGARISM DSGTENMDWV AAALKRIVEF TQDGGEINVV VSGINVGAQP YWNAEATMLM
HTKGVLIMTP DSAMVLTGKQ ALDFSGGVSA EDNFGIGGHD RVMGPNGQAQ YWAPNLTGAR
DILMSHYDHT YIAPGETTPR RAPTIDPVDR DIREFPHTVE GSDFSTVGEI FSADTNPDRK
KPFDIRTVMR ALSDQDHPVL ERWAAMADAD TAVVHDVHLG GIPVCLLGIE SRSVPRRGFP
PTDGPDSYTA GTLFPQSSKK AARAINAASG NRPLVVLANL SGFDGSPESL RKLQLEYGAE
IGRAIVNFRG PIVFCVISRY HGGAFVVFSK TLNPMMTVLA VEGSFASVLG GAPAAAVVFS
RDVDARTAGD PRVRDLEARV GAATGADRAA LTAELDELRS SVRAEKVGEV AAEFDRVHDI
RRAVEVGSVD AVVRAAELRP RIIEAIESRL R
//
