ID A0A372IWR6_9ACTN Unreviewed; 463 AA.
AC A0A372IWR6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=QacE family quaternary ammonium compound efflux SMR transporter {ECO:0000313|EMBL:RFU19400.1};
GN ORFNames=D0Z06_21775 {ECO:0000313|EMBL:RFU19400.1};
OS Geodermatophilus sp. LHW52908.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Geodermatophilus.
OX NCBI_TaxID=2303986 {ECO:0000313|EMBL:RFU19400.1, ECO:0000313|Proteomes:UP000262362};
RN [1] {ECO:0000313|EMBL:RFU19400.1, ECO:0000313|Proteomes:UP000262362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW52908 {ECO:0000313|EMBL:RFU19400.1,
RC ECO:0000313|Proteomes:UP000262362};
RA Li L., Lin H.W.;
RT "Geodermatophilus marinus sp. nov., isolated from marine sponge Leucetta
RT chagosensis.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC {ECO:0000256|RuleBase:RU003942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFU19400.1}.
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DR EMBL; QVQH01000029; RFU19400.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A372IWR6; -.
DR OrthoDB; 21828at2; -.
DR Proteomes; UP000262362; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561:SF0; GUANIDINIUM EXPORTER; 1.
DR PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000262362};
KW Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 463 AA; 45297 MW; F3019D2789D04A4E CRC64;
MHSDRNARLT PALPVLLAVL VALLLTAFAW PAVRSAPRDV PVAVAGPPAA TAQLGDALAG
QQPGALALEP VPDESAARAS IRDREVYGAV VLDAAGPPRV LVASAASPAV AQALGQVAAG
LGAATGAQVS VEDVVPAPAS DPRGAGLAAG ALPLAIGGIA TAALAGLLVG PVRRRVAVVL
GAAVLGGMAA ATVLGTWLGA LEGSWWALAG AAGLGIAATG LALTGLRAVG GMPAFGLGAA
TVVLLGNPLS GLSSAPELLP AGWGALGQLL PPGATGSLLR SVSWFDGAGA GGPLLVLGTW
AVAGLLLSAV GAARSRPRAA AAPPEHAVPG LGGWLRARPA PGRAAPYPDS DKTAATEVVV
PWLVLILSGV LEAVWATALG RSEGFTRLWP TVVFGVAVVA SMVGLAYAMR ELPVGTSYAV
WVGIGAVLTV AVAMVTGEEP VSAVRLLLLA GIIGCVAGLK ALD
//
