ID   A0A372JEE1_9ACTN        Unreviewed;      1223 AA.
AC   A0A372JEE1;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
DE   Flags: Fragment;
GN   ORFNames=DZF91_27995 {ECO:0000313|EMBL:RFU38383.1};
OS   Actinomadura logoneensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=2293572 {ECO:0000313|EMBL:RFU38383.1, ECO:0000313|Proteomes:UP000261811};
RN   [1] {ECO:0000313|EMBL:RFU38383.1, ECO:0000313|Proteomes:UP000261811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEAU-G17 {ECO:0000313|EMBL:RFU38383.1,
RC   ECO:0000313|Proteomes:UP000261811};
RA   Shi L.;
RT   "Actinomadura jelena sp. nov., a novel Actinomycete isolated from soil in
RT   Chad.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFU38383.1}.
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DR   EMBL; QURH01000816; RFU38383.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A372JEE1; -.
DR   Proteomes; UP000261811; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0018580; F:nitronate monooxygenase activity; IEA:InterPro.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 2.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR004136; NMO.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR   PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF03060; NMO; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000261811}.
FT   DOMAIN          724..1165
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   REGION          305..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          695..719
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..716
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1223
FT                   /evidence="ECO:0000313|EMBL:RFU38383.1"
SQ   SEQUENCE   1223 AA;  125620 MW;  22B2AB30DDCC7F76 CRC64;
     MAAEVDPGGA FGTGAADRSR ALEAEILGVG PFGRPAPHLA AAVCRAGGLG VLDLGTDRAA
     ALAALADLTR WWRGAFGVRV QAGCGVRPDE LPDQARTVLL DAVSAEETIG YTRGRRLLVE
     VVDAAEASAA RAAGADGLIA RGCEAGGRIG ELTTFVLLQR LLGDPGTTLP VFAAGGIGPH
     TAAAAVAGGA AGVVLDVQLA LVRECELPCD VADALRAMDG SETRVTGGHR IFARPDLPDF
     DLTGLAPAEA NTRLGASGLH VKALPVGQDG FLAAALAHRY RTAGGVVQAV REHLGTHLRA
     ALTARPLAPR DDTSDASDVS DAPGESGVAG PVYPVVQGPM TRVSDRSAFA AAVAQDGGLP
     FLALALMGGD EVRDLLAETA DRLAGRPWGV GVLGFAPPEL REAQIEAVLA ARPPYALIAG
     GRPAQAAPLE DAGIATYLHV PSPGLLERFL GEGARRFVFE GLECGGHVGP RASFPLWEAQ
     VQRLTDFTDR HPGTAAEMSV LFAGGVHDER SGAMVAALAG PLAARGVDVR VLMGTAYLFT
     HEAVAAGAIM PGFQQAALEC AGTTLLETSP GHATRCARTP YVDAFEQARR GLEAAGTSRR
     RMWEQLEELN LGRLRIAAKG LRRGRGGGPL EPVGAGEQAR EGMYMLGQVA ALRSATTSVT
     ALHEQVTAGA QRFLEARAAE LGVVVPADAA IGAATSATSA TPTTSGLTSG SEASGRRSAS
     APAPADVAII GIGCVFPQAG DADEYWANIV RGVDSVTEVP ASRWDPAVFY DPASRTGEKS
     PSKWGGFVPD VPFDAFAYGI PPNSLGSIEP TQLLALEVAA RALRDAGYDE RPFDRSRTAV
     VFGSEAGTEL GTAYSVRALL PKYFGEVPPG VDGQLPRLTE DSAPGVLTNV IAGRIANRLD
     LGGANYTVDA ACAASLAALD AACKELVTGA ADMVLCGGAD LHNGIYDYLL FSSVHALSRQ
     GRCATFDASA DGIALGEGVA CVVLKRLADA ERDGDRVYAV VKAVAGSSDG RSLGLTAPRV
     QGQRLALERA YERAGVHPSR VGLVEAHGTG TEVGDRTELA TLTETFTEAG AAPGSVTLGS
     VKSQIGHTKC AAGLAGLIKT AYALHTGVLP GTLHLTEPNK AWDGTSSPFA FGRAARPWAA
     APGERFAGLS GFGFGGSNFH AVLAGYDGAP EPVSGLAAWP AELLLVRGAD RDAARTALDR
     LAALADVPGA RLRDLARTLA EPN
//