ID A0A372JLG4_9ACTN Unreviewed; 547 AA.
AC A0A372JLG4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Bifunctional 3'-5' exonuclease/DNA polymerase {ECO:0000313|EMBL:RFU40857.1};
GN ORFNames=DZF91_15060 {ECO:0000313|EMBL:RFU40857.1};
OS Actinomadura logoneensis.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=2293572 {ECO:0000313|EMBL:RFU40857.1, ECO:0000313|Proteomes:UP000261811};
RN [1] {ECO:0000313|EMBL:RFU40857.1, ECO:0000313|Proteomes:UP000261811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEAU-G17 {ECO:0000313|EMBL:RFU40857.1,
RC ECO:0000313|Proteomes:UP000261811};
RA Shi L.;
RT "Actinomadura jelena sp. nov., a novel Actinomycete isolated from soil in
RT Chad.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFU40857.1}.
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DR EMBL; QURH01000255; RFU40857.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A372JLG4; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000261811; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:RFU40857.1};
KW Hydrolase {ECO:0000313|EMBL:RFU40857.1};
KW Nuclease {ECO:0000313|EMBL:RFU40857.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261811}.
FT DOMAIN 307..506
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 103..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 58633 MW; 2D74F65D4B8230BC CRC64;
MRIAIAIGAG GGGALRPLAD DGTPLAAAES VPSLVAAVAE RQRADRPRWV WSSSARVYRA
LVEAGVRVER CHDLELTESL LSGYDGRYGE PRSVAAAWAR MRGEPVPDDR PPAESGPQAS
LFDDEEDEGE DLEQIVAVHA EQQRRIARVP GFALLCAAES AGSLIAAEMT HAGLPWSAAA
HDALLTEMLG PRPSGGLRPR RLQELADKIS AAFGRHVNPD SPAQIVKAFA AVGHPVKTTR
AYVLKEIDHP AVPLLLEYKE LSRLHTAHGW AWLDTWVHEG RFRPEYVVGG VVSGRWATNG
GGALQIPRVL RSAVVADEGW SLVVADAAQL EPRVLAALAG DRAFADAAAQ GDLYAALADV
FTPSADLTAR DKAKLALLSA MYGGGTGEAV QLLGVLKKRF PDAFEFVEAA AQAGERGHLV
RSRLGRTCPP PSADWRELTS TGEDTRSASA VRSRGRFTRN FVVQATAADW ALTLMARLRQ
RLTALGDPHL VFFQHDEVIV HTPTSLADEV VAAIEASAKE AGRLLFGETP VVFPMEAAVV
QRYSDAK
//
