ID   A0A372KC29_9BURK        Unreviewed;       824 AA.
AC   A0A372KC29;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Spermidine synthase {ECO:0000313|EMBL:RFU49839.1};
GN   ORFNames=D0B32_03805 {ECO:0000313|EMBL:RFU49839.1};
OS   Paraburkholderia sp. DHOC27.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=2303330 {ECO:0000313|EMBL:RFU49839.1, ECO:0000313|Proteomes:UP000263097};
RN   [1] {ECO:0000313|EMBL:RFU49839.1, ECO:0000313|Proteomes:UP000263097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DHOC27 {ECO:0000313|EMBL:RFU49839.1,
RC   ECO:0000313|Proteomes:UP000263097};
RA   Gao Z.-H., Qiu L.-H.;
RT   "Paraburkholderia sp. DHOC27, isolated from subtropical forest soil.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC       {ECO:0000256|ARBA:ARBA00007867}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00354}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFU49839.1}.
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DR   EMBL; QVQV01000001; RFU49839.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A372KC29; -.
DR   OrthoDB; 5516475at2; -.
DR   Proteomes; UP000263097; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008295; P:spermidine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR030374; PABS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF037959; MFS_SpdSyn; 2.
DR   PANTHER; PTHR43317:SF9; POLYAMINE AMINOPROPYLTRANSFERASE 2; 1.
DR   PANTHER; PTHR43317; THERMOSPERMINE SYNTHASE ACAULIS5; 1.
DR   Pfam; PF01564; Spermine_synth; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51006; PABS_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Polyamine biosynthesis {ECO:0000256|ARBA:ARBA00023115, ECO:0000256|PROSITE-
KW   ProRule:PRU00354}; Reference proteome {ECO:0000313|Proteomes:UP000263097};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU00354}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        63..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        102..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        166..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        429..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          441..691
FT                   /note="PABS"
FT                   /evidence="ECO:0000259|PROSITE:PS51006"
SQ   SEQUENCE   824 AA;  86942 MW;  962BF6A8259C743D CRC64;
     MLLLLVSGAA SLIYQLLWIK QLSLVVGVEV QAVTIGISGF FAGMALGGWL FGKLADRSAR
     PLLLYAALEG GALLLALACT FGLAHAALLF VTLQKLTGPL AWALPFALVG VPAILMGGTL
     PVLMRALAPR ENLIGHAGAR LYAANTAGAI AGTLVAPFVL IPWLGVQGAA CAAAVLNCVA
     MLAALLLAPG GRARVAERAF ASVDARSADD TSPTAHQAHL ALVIYALAGG IGLGYEVIWS
     QTIVQFIGTR SFAFAVVLAT YLLGLALGSA LVARRVDRAR DAWGSFGLLI AAAGVVALVE
     LAVLGQWLPR WQADAAQAVM NATGNLLATM CARFAVASLA IVFVPTVLLG AAFPFALRLT
     VHARRTGRDV GAVVALNTAG GIAGSLLAGF VLLPALGLIH ALAALAILAS VLGLLAVFGG
     HAMQRGARWG VPLLAALAVI ASILTPADRL AAMLATAHGG ALRFYEESAG GTVAVIEQTS
     GDNHFNRLYI QGVSNSGDAM TSLRYMRMQA LLPLLIHRDT PRSVLVIGLG TGITSGALLT
     WPGLEQRVVA ELLPAVVRAS AQFKGNYGVT NDPRVQIRLH DGRHELLSST QRYDLITLEP
     PPPSAAGIVN LYSSDFYRLA ASRLNDGGLV AQWLPLATQN EADTRSLIKS FVQTFPYATL
     WTTELHEMML VGSMQPITLD LPGIRARFAQ PEVAKALGEV GIASPAALMS TWVTDRAGLE
     YYAADAPEVT DDKPRIEYAK WVDEREFPRV LARLLALHIE PPVVGADDAF RAAMQTEQGT
     LQTFYKAALD AYQGDRGAWQ DDIARVMQAD GDNPYYRWFV GMGG
//