ID   A0A373LL42_9FIRM        Unreviewed;       326 AA.
AC   A0A373LL42;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=RluA family pseudouridine synthase {ECO:0000313|EMBL:RGF51100.1};
GN   ORFNames=DW006_06950 {ECO:0000313|EMBL:RGF51100.1};
OS   Eubacterium sp. AF36-5BH.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=2293108 {ECO:0000313|EMBL:RGF51100.1, ECO:0000313|Proteomes:UP000262191};
RN   [1] {ECO:0000313|EMBL:RGF51100.1, ECO:0000313|Proteomes:UP000262191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF36-5BH {ECO:0000313|EMBL:RGF51100.1,
RC   ECO:0000313|Proteomes:UP000262191};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|ARBA:ARBA00010876}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RGF51100.1}.
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DR   EMBL; QTVG01000005; RGF51100.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A373LL42; -.
DR   OrthoDB; 9807829at2; -.
DR   Proteomes; UP000262191; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR21600:SF92; 21S RRNA PSEUDOURIDINE(2819) SYNTHASE; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000262191};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT   DOMAIN          93..256
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
SQ   SEQUENCE   326 AA;  37375 MW;  6BBE2184EB600889 CRC64;
     MKEIIIEKNQ AGQRFDKFLF KYFKEAPSSF IYKMLRKKNI VLNGKKSDGK DKLKEKDSIK
     IFMAEDTIAK FKGEHKTNIV KPVKLDIVYE DDNVLFINKP AGMLSQKAND NDVSLNEYVI
     SYLVNSGQIT EQNLETFKPA VCNRLDRNTS GLIVAGKSLE GLQIMSKMFK ERTMDKYYLA
     VVSGYVDSSM NIKGYLSKNS KTNKVTISQA ENNGDYIETA YEPLEYKKGL KQAGITVLKV
     KLVTGKPHQI RAHLASINHP IIGDYKYGKK EINDKYKETY GIKNQMLHSW QLIFEKVEGS
     CRNLSYKTFV ARPSKEYANF IDFQNK
//