ID A0A373N8Y0_9FIRM Unreviewed; 964 AA.
AC A0A373N8Y0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=GTP-binding protein {ECO:0000313|EMBL:RGF70884.1};
GN ORFNames=DWZ38_19275 {ECO:0000313|EMBL:RGF70884.1};
OS Ruminococcus sp. AF31-8BH.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=2293174 {ECO:0000313|EMBL:RGF70884.1, ECO:0000313|Proteomes:UP000262205};
RN [1] {ECO:0000313|EMBL:RGF70884.1, ECO:0000313|Proteomes:UP000262205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF31-8BH {ECO:0000313|EMBL:RGF70884.1,
RC ECO:0000313|Proteomes:UP000262205};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGF70884.1}.
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DR EMBL; QTVN01000020; RGF70884.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A373N8Y0; -.
DR OrthoDB; 9801472at2; -.
DR Proteomes; UP000262205; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd10912; PIN_YacP-like; 1.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR010298; YacP-like.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF05991; NYN_YacP; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000262205}.
FT DOMAIN 10..265
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 694..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 108660 MW; 222E6FAC4DDD4857 CRC64;
MAETFGKNPE KNLSIGILAH VDAGKTTLSE ALLYLSGKIR KLGRVDHKDA YLDTSPLERE
RGITIFSKQA ILDLGDTRVT LLDTPGHVDF SAEMERTLQV LDYAILVING ADGVQGHTVT
LWRLLERYQI PTFIFINKMD QDGADQEALL AELRKRLSEN CLDFGPMDIK TEIQKETDPG
SRAEQNTNEI FHTEAEHGEE FWESLAMCDE HLLEKYLEEG EVGPEEVTRL IIERKVFPCY
FGSALKMGGV KYLIGGLEHY TANPLYPEAF GAKVYKIARD EQGNRLSYMK ITGGTLKVKD
LLTTSKGNVA AGEEIWEEKA DQIRIYSGAK FELAKEAKAG TVCAVTGLTH TFPGQGLGIT
ENSNMPVLEP VLNYRILLPE GCDVHQMLKK LKELEEEDPQ LHIVWDEQLG EIHAMLMGDV
QIEILKRLIW ERFHVAVDFG TGNIVYKETI AAPVEGVGHF EPLRHYAEVH LLLEPGEPGS
GLQFFTACSE DVLDRNWQRL ILTHLEEKEH RGVLTGAPIT DMQITLLTGR AHQKHTEGGD
FRQATYRAIR QGLKKATSVL LEPYYEFRLE IPVDTVGRAM TDIQKMQGTL LPPETEDMTA
ILKGKAPVSA MRDYQKEVVS YTRGLGRLFC SLKGYEPCKN QEEIVEQIGY DSERDLDNPT
GSVFCAHGAG FVVPWYQVEE YMHLDTGISE EFDDLSAEED WQSTESGEEN AAYGGAGSQS
GNQARGASQT SGKSGYQPPK SAYRGSYEDD KELQAIFERT FGPVKRDRMS SYKKVVTAPS
SPSTSSYRKK DKEEYLLVDG YNIIFAWPEL KELADADVRA AQTKLMDILS NYQGYKKCTL
ILVFDAYKVE GHQEEVLTYH NIHVVYTKEA ETADQYIEKT VHKIGRQHQV TVATSDGLEQ
IIIMGQGANR ISARGLKEEI EETRKQLRQE WHQRRQSSHT YLFDHADEET AKLMEEVRLG
KKKL
//
