ID   A0A373VK89_9FIRM        Unreviewed;      1276 AA.
AC   A0A373VK89;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Nuclease SbcCD subunit C {ECO:0000256|ARBA:ARBA00013368};
GN   ORFNames=DWX28_11220 {ECO:0000313|EMBL:RGG60938.1};
OS   Blautia sp. AF19-10LB.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=2292961 {ECO:0000313|EMBL:RGG60938.1, ECO:0000313|Proteomes:UP000262342};
RN   [1] {ECO:0000313|EMBL:RGG60938.1, ECO:0000313|Proteomes:UP000262342}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF19-10LB {ECO:0000313|EMBL:RGG60938.1,
RC   ECO:0000313|Proteomes:UP000262342};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000256|ARBA:ARBA00011322}.
CC   -!- SIMILARITY: Belongs to the SMC family. SbcC subfamily.
CC       {ECO:0000256|ARBA:ARBA00006930}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RGG60938.1}.
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DR   EMBL; QTWS01000019; RGG60938.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A373VK89; -.
DR   Proteomes; UP000262342; Unassembled WGS sequence.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041796; Mre11_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   PANTHER; PTHR32114; ABC TRANSPORTER ABCH.3; 1.
DR   PANTHER; PTHR32114:SF2; ABC TRANSPORTER ABCH.3; 1.
DR   Pfam; PF13476; AAA_23; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172}.
FT   DOMAIN          1..225
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          414..673
FT                   /note="Rad50/SbcC-type AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13476"
FT   COILED          622..673
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          701..791
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          918..952
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          997..1031
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1276 AA;  145675 MW;  C489937B05CFFE64 CRC64;
     MKILHTADWH IGQFKGPVVD GVNLRLQDTV KCLEYMVEVA QKEKPDIVCI SGDIFHQEQI
     GPVRYSDEMI IATDTITKLA DIAKGVIVMR GTPNHDGSGQ FRVLDRMFVK TSHVHIITAP
     TVLHTPYTDI ACIPGFDKQE FRAKFPGLSA DEENLAWTKY ISDMVFALRA ECEKTPILMA
     HYTVPGCNME SGQTSFFTNF EPVIPREALM AARYEAVLLG HIHRPQIIEG FDNVFYSGAI
     NAMNFNDEGQ ERGFWIHEFN EKGTLVKGHR YTTPYRQFHT ITWDPDEVGD YIREGAMYLH
     RTGISEEVTD KIVRVRYSCT SEQKKALNIP LLQKNLYELG AFYVADIEAE STIDITNRGL
     LSEESDPRLN LKKWLEEKTF KNPDKIVELA EPIIAEAMKQ STTAEIHGVF KPVSISVRNY
     RNYKEENFDF SDISFCTING VNGAGKSSLF MDAIVDCLFE ETREGDCKAW IRGTEDARSG
     FIEFIFDIGE KRFRVVRTRT KSGKPTLNLS QYQEESADWM NLSKERIIDT QAEIEKLLGM
     DSMTFRSCAL IMQDQYGLFL QAKKDERIAI LGNLLGLGIY GVMELDARKK LADSRKELVS
     KKEAVRIKTD FIKAQGKPEE ELKTVEKDIL KNQEELENLD ESRRNLIERQ EKISEAEKES
     EKIRSDLKEC SEEYSAMAND LDHSKQTLTA CNNLLELADV IREKAKQHSE LSLQLSEVEK
     DVIKYKNAKR TLDSYNEDID RYQRLIDKNK FRNKQIHLQI SQLALNVPED LEERLDALAN
     ERKEIESQQE KRYLYSTAQN ELHEIDSSYS QKISGAVNRR DHRQKRISEI RQQEEFMKNS
     GCPDIESASC RFLSKAVEDV KSLPVELDNL KKCEEEIEIL TSERNQKIAD KQEKIKNIEY
     DPKRLAILTA SVTELSKYER IKKDAEQNKL EIARLEAEKE SNDKNIGQCE ENLLQVKLKA
     SEITETVNKL SGSVDRQEQI KQQMAHLQTY VEQEKELPVY EERKQHVLER IENMEKEMEK
     LTDRKFILSS QLTGMDTMIE KMKETFSADM VEETDRQIRS NKETLGELQI QKGVLLERLE
     NIDTMRGEIS MLNNEIAVAA GRADCYEALK QAFSQDGVPH QIIRNIIPHI TDTTNNILGQ
     MTGGTMGVEF VMERTVKGKD GDKATLDVLI NEYGKTTLPY ASKSGGEKVK ASLAVILALS
     EIKATAAGIQ LGMLFIDEPP FLDDEGAQAY VDALETIRDR YSDVKIMAIT HDDAMKARFG
     QAVTVIKTDD GSKVIY
//