ID   A0A373VKS2_9FIRM        Unreviewed;       598 AA.
AC   A0A373VKS2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=BlaR1 family beta-lactam sensor/signal transducer {ECO:0000313|EMBL:RGG61171.1};
GN   Name=blaR1 {ECO:0000313|EMBL:RGG61171.1};
GN   ORFNames=DWX28_10440 {ECO:0000313|EMBL:RGG61171.1};
OS   Blautia sp. AF19-10LB.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=2292961 {ECO:0000313|EMBL:RGG61171.1, ECO:0000313|Proteomes:UP000262342};
RN   [1] {ECO:0000313|EMBL:RGG61171.1, ECO:0000313|Proteomes:UP000262342}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF19-10LB {ECO:0000313|EMBL:RGG61171.1,
RC   ECO:0000313|Proteomes:UP000262342};
RA   Zou Y., Xue W., Luo G.;
RT   "A genome reference for cultivated species of the human gut microbiota.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M56 family.
CC       {ECO:0000256|ARBA:ARBA00011075}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RGG61171.1}.
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DR   EMBL; QTWS01000017; RGG61171.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A373VKS2; -.
DR   Proteomes; UP000262342; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   CDD; cd07341; M56_BlaR1_MecR1_like; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR008756; Peptidase_M56.
DR   PANTHER; PTHR34978; POSSIBLE SENSOR-TRANSDUCER PROTEIN BLAR; 1.
DR   PANTHER; PTHR34978:SF3; SLR0241 PROTEIN; 1.
DR   Pfam; PF05569; Peptidase_M56; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        37..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        116..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          10..309
FT                   /note="Peptidase M56"
FT                   /evidence="ECO:0000259|Pfam:PF05569"
FT   DOMAIN          391..592
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   598 AA;  68304 MW;  77EC41526AAC0BFE CRC64;
     MSNWIIHFLI SNIFICIFTL VIIGTKKLLK KYLSATTQYH LCFLLFLLLA VPFFPVQIHG
     SQLFSWLHFF QTDSGLNSGT DTLSELTSNT QNILLNQVND FSVSISSQFS GGLNTILFLI
     WITGVMIMSV LTLHSLNYVR SIKRSALPLQ NQQVKTIYYN CLKELKISHP VSVYSTAFLK
     SPVLIGIIHP RIYIPIHLIS ELNPDDMRFM LLHELQHYRH KDTFIGFLMV ISNILYWFNP
     FVWYTLKEIL CDREIACDSA VLQMISADEY QAYGTTLINF AEKISSFSSP LAVGMSGNFR
     QMKRRILNIA VFRKETLYQK MRALIIYLVI SAVFIGCTPI LSIDASTQNV YHFSDTDKNI
     SLLDISETFG TYDGSFVLYD NNLDSWKIYD LEEATKRIPP ESTYKIYDAL LGLESGIITP
     EHSSMTWNGD AFPFPSWEAD QDLNSAMQNS VNWYFQAIDS QLGINRVQEF LNKIEYGNQT
     TSSNLDLYWS DFSLKISPLE QVTLLKKFNT NEFHLNSQNV FSVKNAIKIA STPNGNFYGK
     TGTGRVNGQD INGWFIGYVE TSDNSYYFAT NIQSDSNATG KKAFEITSDI LKKLHIWN
//