ID A0A374WB85_9BACE Unreviewed; 774 AA.
AC A0A374WB85;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tyrosine protein kinase {ECO:0000313|EMBL:RGN49277.1};
GN ORFNames=DXB63_07030 {ECO:0000313|EMBL:RGN49277.1};
OS Bacteroides sp. OM05-12.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=2292283 {ECO:0000313|EMBL:RGN49277.1, ECO:0000313|Proteomes:UP000264777};
RN [1] {ECO:0000313|EMBL:RGN49277.1, ECO:0000313|Proteomes:UP000264777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OM05-12 {ECO:0000313|EMBL:RGN49277.1,
RC ECO:0000313|Proteomes:UP000264777};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGN49277.1}.
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DR EMBL; QSUN01000005; RGN49277.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A374WB85; -.
DR Proteomes; UP000264777; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RGN49277.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000264777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..104
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 578..709
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 774 AA; 87455 MW; B3BC1F8F8381965A CRC64;
MNMNLEEEEE HIDYLEIIRR YLVHWKLIIC SLLICMTIAF IYLRYATPVY NVYSIIMLKD
NERGGRADEL SVLQSWGIMG AGDNVDNELE ILRSWNLTRE VVKEMQLYIT YNYKGHFKYE
DLYKSSPINV FVNVESLDTL SAPLKMTIRE SGNGQIIVEG KYREDSFNRT LEKLPGDILT
PIGKITFVRN PDNQLESGNT LYVKVLNPNI IIGSFLGRLS VETTSKTTSA ICLSINETNV
DRGIDFVTKL VEVYNREAIE DKNKVAQNVE TFINERLTKI GVELSYVKED LENYKINEGI
IDVKVNAQLS LQENTLYRKE LVALETQLKL VKYLEQFMKE DNGVERLVPT NVGIEDQTLQ
ELIKEYNTKL MERNRLLRAS SSQNPTVLIL TKTITELKKD LLSSISSIQD ALMISRDDLN
KQILIYNDRI INVPTQEREL SERLRNEKVK TDLYAILSRK REENALTMAI SSEKARVIND
PMITGPVSPK RSHVYILAFA LGFAIPVGGL YLYNLLNIHV RNRKELEALT DVSVLGEIPV
YAKKEVIAVK EGVNDLMAEA FRTVRANLQF MGGNAASKVI MVTSSMPGEG KTFISVNLSV
SLALIGKRVL LVGMDIRKPM LAEILSLNPK KGVTDYLACI RNDVSELVQP SGIRSNFHVL
VSGTIPPNPA ELLQSERLTE LMETLRQEYD YIIVDSAPIG LVSDSFLMHS VIDSTIYVTR
ENYTEKKHLE WLNDIAGNKK LPSPHIIINA VSLENIGGHG ASYGYGGYGE NTVS
//
