ID A0A376BMI8_9NEIS Unreviewed; 1375 AA.
AC A0A376BMI8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=recQ_2 {ECO:0000313|EMBL:SSY70855.1};
GN ORFNames=NCTC10283_00970 {ECO:0000313|EMBL:SSY70855.1};
OS Alysiella crassa.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Alysiella.
OX NCBI_TaxID=153491 {ECO:0000313|EMBL:SSY70855.1, ECO:0000313|Proteomes:UP000254209};
RN [1] {ECO:0000313|EMBL:SSY70855.1, ECO:0000313|Proteomes:UP000254209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10283 {ECO:0000313|EMBL:SSY70855.1,
RC ECO:0000313|Proteomes:UP000254209};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UFSO01000002; SSY70855.1; -; Genomic_DNA.
DR STRING; 1120980.GCA_000745955_01174; -.
DR Proteomes; UP000254209; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000254209}.
FT DOMAIN 52..230
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 260..407
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 825..1154
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 846..853
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1375 AA; 156657 MW; 2013EDDE3205BA0C CRC64;
MASILRQIRG TPCAEHCPYC QTHLNAERHL QKYFAYPSFR EYNGKPLQAQ AAQAAIAHQS
LLAIFPTGGG KSVTFQVPAL MAGEHSKALT VIISPLQSLM KDQVDNLEQR GITEAVTING
LLDPIERQKA VQRVQDGSAS LLYISPESLR SRTIEHLILG RNVARFVIDE AHCFSAWGQD
FRVDYLYIAE FIQRIQTHKQ HAIPVSCFTA TAKPQVVEDI KQYFKKNLDL DLQVFAADVG
RKNLHYQVLP QKNDDERYQT LRHLIQQHNC PTIVYVSRTR KTQELAQQLM QDGFAALPYH
GKMENEQKIA NQNAFMTGEA QIMVATSAFG MGVDKKDVGL VVHYEISDSL ENYVQEAGRA
GRDEQIQAAC FVLFQLEDLD KHFILLNQTK ISQKEINQIW KAIKDLCGKR SQITESALNI
AKQAGWQDEH IDEIETRVKT AIAALENAGY VKRGQNMPCV YANSILAKNA QEAIEKIAQS
QIIHPDQKSH AVRVIKKLFS QRSQIHATDE QAESRVDYMA DVLGLKTETV VKIVSWLRME
GILADQQDLR AFIRHNGRSQ DVITRLSHLA DLERALLAQF KEHDGVLHTS YKALNQLFSG
SLKFSNPKII KSLLAFWKIK NWLGRAETQY DEIALAMKLP LPDVAQWLER KHFLAQFAVR
YLHDLRDLSH QAAAENPDLA YVEFSLGGLQ KAFAQQNLSD IATLEEWEDV LFYLVRMDLL
KIEGGFLVVY QRLHVQRLIA DNRKQYTKDD YTQLAHYYQM RQEQIHIVGK YAQTMMNDVQ
AALKLVRDYF SLDYRQFLRH YFPAQESESL KRNMTAARFE QWFGNLSPEQ RQIIQDNQSQ
HIVVFAAPGS GKTRVLVHKL ASLYQLEDVK HEQLLMLTFS RAAAHEFKSR LFDLIGNAAA
YVEIKTFHSY CFDLLGRVGD LQQSDDIIAQ AIAKIQSGEV ESTRIAKLVL VLDEAQDINA
TQFELVKTLM AHNEDMRVIA VGDDDQTIYD FMGASPHYMQ TLLRDFGATK YELLANYRSK
SEIVRFCNHF ASHISQRLKE NDVAAVQTET GQVEYVAFSG SVLPLLLDKV QAAQGHSVAV
LTHTNEEAIW LAGELKQAQI PCKLVQGNDG FRVHDLLEVR VFEHFLALHG KAVIDEIAWQ
TAKQRAQTHF SRSQHLSLLN NLLGDFEHTH PKTKYVSDWY NFVQESALEN FDRAHQASVH
VSTIHKAKGR EYDDVLVYLN QAACERDEQK RLLYVAFSRA KSHLCIFANH AHLHKMCANV
GAEIPFYRGE AIAPARELAL YLNHGDVNLG RFAACARAVR ALQAGDKLLA DGEKCCDLSG
NAVLYFSKKF REKLAHYQQS YYQISHAEVN FIVLWHNKEN DETSRIVLPI VYLRR
//
