ID A0A377KIP0_9ENTE Unreviewed; 624 AA.
AC A0A377KIP0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Tyrosine decarboxylase {ECO:0000313|EMBL:STP29085.1};
DE EC=4.1.1.25 {ECO:0000313|EMBL:STP29085.1};
DE EC=4.1.1.86 {ECO:0000313|EMBL:STP29085.1};
GN Name=ddc_2 {ECO:0000313|EMBL:STP29085.1};
GN Synonyms=tdc {ECO:0000313|EMBL:NAA79463.1};
GN ORFNames=EA71_00340 {ECO:0000313|EMBL:RCA12136.1}, GUJ97_02550
GN {ECO:0000313|EMBL:NAA79463.1}, NCTC8129_01274
GN {ECO:0000313|EMBL:STP29085.1};
OS Enterococcus durans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=53345 {ECO:0000313|EMBL:STP29085.1, ECO:0000313|Proteomes:UP000254070};
RN [1] {ECO:0000313|EMBL:RCA12136.1, ECO:0000313|Proteomes:UP000252797}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4EA1 {ECO:0000313|EMBL:RCA12136.1,
RC ECO:0000313|Proteomes:UP000252797};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Van Tyne D., Lebreton F., Saavedra J.T., Gilmore M.S.,
RA Manson Mcguire A., Clock S., Crupain M., Rangan U., Young S.,
RA Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., Shea T.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus durans 4EA1.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:STP29085.1, ECO:0000313|Proteomes:UP000254070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC8129 {ECO:0000313|EMBL:STP29085.1,
RC ECO:0000313|Proteomes:UP000254070};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:NAA79463.1, ECO:0000313|Proteomes:UP000444134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A60 {ECO:0000313|EMBL:NAA79463.1,
RC ECO:0000313|Proteomes:UP000444134};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR602129-50};
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DR EMBL; WXTH01000005; NAA79463.1; -; Genomic_DNA.
DR EMBL; LEPB01000001; RCA12136.1; -; Genomic_DNA.
DR EMBL; UGIF01000002; STP29085.1; -; Genomic_DNA.
DR RefSeq; WP_005875437.1; NZ_WXTW01000002.1.
DR STRING; 53345.LIU_00045; -.
DR GeneID; 56742964; -.
DR KEGG; edu:LIU_00045; -.
DR Proteomes; UP000252797; Unassembled WGS sequence.
DR Proteomes; UP000254070; Unassembled WGS sequence.
DR Proteomes; UP000444134; Unassembled WGS sequence.
DR GO; GO:0004058; F:aromatic-L-amino-acid decarboxylase activity; IEA:UniProt.
DR GO; GO:0033983; F:diaminobutyrate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0004837; F:tyrosine decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR021115; Pyridoxal-P_BS.
DR InterPro; IPR049373; TyrDC_C.
DR InterPro; IPR022397; Tyrosine_deCO2ase_bac.
DR NCBIfam; TIGR03811; tyr_de_CO2_Ent; 1.
DR PANTHER; PTHR42735; -; 1.
DR PANTHER; PTHR42735:SF4; TYROSINE DECARBOXYLASE; 1.
DR Pfam; PF00282; Pyridoxal_deC; 1.
DR Pfam; PF21391; tyr_de_CO2_C; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:STP29085.1};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50}.
FT DOMAIN 470..610
FT /note="L-tyrosine decarboxylase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21391"
FT MOD_RES 389
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ SEQUENCE 624 AA; 70190 MW; 8B577FDCF8FD24CA CRC64;
MESLSNDLNL NALFIGDKAE NGQIYKALLN DLVDEHLGWR QNYMPQDMPI ITPEEKSSAS
FEHTVNRTKD VLSEISARMR THSVPWHNAG RYWGHMNSET LMPSLLAYNF AMLWNGNNVA
YESSPATSQM EEEVGLEFAK LMSYKDGWGH IVADGSLANL EGLWYARNIK SLPLAMQEVT
PELVAGKSDW ELMNMSTKEI MDLLDSVPDK IDDIKAHSAR SGKNLQKLGK WLVPQTKHYS
WLKAADIIGV GLDQVIPVPV DHNYRMDINE LEKIVRGLAA EKTPILGVVG VVGSTEEGAI
DGIDKIVELR RVLEKDGIYF YLHVDAAYGG YGRAIFLDED NNFIPFEELK DVHFKHNVFT
ENKNYILEEV HSAYKAIEEA ESVTIDPHKM GYVPYSAGGI VIKDVRMRDV ISYFATYVFE
KGADIPALLG AYILEGSKAG ATAASVWAAH HVLPLNVTGY GKLMGASIEG AHRFYNFLNN
LSFKVGDKEI EVHPLTYPDF NMVDYVFKEK GNDDLVAMNK LNHDVYDYSS YVKGSIYGNE
FLTSHTDFAI PDYGNSPLQF VNQLGFSDEE WNRAGKVTVL RASVMTPYMN KEEHFEEYAE
KIKAALQEKL EKIYADQLLA SEAK
//
