ID A0A377R6B6_9NEIS Unreviewed; 400 AA.
AC A0A377R6B6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Putative protoheme IX biogenesis protein {ECO:0000313|EMBL:STR03105.1};
GN Name=hemY {ECO:0000313|EMBL:STR03105.1};
GN ORFNames=NCTC13336_02000 {ECO:0000313|EMBL:STR03105.1};
OS Kingella potus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Kingella.
OX NCBI_TaxID=265175 {ECO:0000313|EMBL:STR03105.1, ECO:0000313|Proteomes:UP000254293};
RN [1] {ECO:0000313|EMBL:STR03105.1, ECO:0000313|Proteomes:UP000254293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13336 {ECO:0000313|EMBL:STR03105.1,
RC ECO:0000313|Proteomes:UP000254293};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
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DR EMBL; UGJJ01000003; STR03105.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A377R6B6; -.
DR OrthoDB; 7053339at2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000254293; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000254293};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..134
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
SQ SEQUENCE 400 AA; 43778 MW; 8E21037304D0B3FE CRC64;
MKALVWILIL FAAAVGLSVA STMFSGNVYF QIGATLARVD LKLFVPALIL VVVLFYILVQ
FFGGLAGIPA RLQRFGTARR SRKAGSSLNA AGLAYFEGRY QKAEQEAAKV LKNKEAGEIR
ALALMIAAHA ADRMNDAGLR GRYLEEISEL PAERQLSRYL LLAEDALNRR DYPAAEANLD
AAAKISPRLT RLLRLQLRYA FDHGDTEAVL DKTAELEKQH AANENEAAQY RDWAYRRLLA
GATDSDGLKR VLKRIPDTLK SGVLCAAVAE KYENLGLYEA AAAWVGKYYP QNGQAALLPP
FVQSVVYLDD KAQRKAVDAA EGWLQERPKD ADLLVSLGLL AYGKQLWGKA QGYLEAGIAE
RDTPQARLAL AKVFDQTGNA AGAENQRLQA LALAHQDTDA
//
