ID   A0A377Z1W4_KLEPO        Unreviewed;       436 AA.
AC   A0A377Z1W4;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=GPH family transporter {ECO:0000313|EMBL:STU59530.1};
GN   Name=yicJ_1 {ECO:0000313|EMBL:STU59530.1};
GN   ORFNames=NCTC5050_00394 {ECO:0000313|EMBL:STU59530.1};
OS   Klebsiella pneumoniae subsp. ozaenae.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=574 {ECO:0000313|EMBL:STU59530.1, ECO:0000313|Proteomes:UP000255382};
RN   [1] {ECO:0000313|EMBL:STU59530.1, ECO:0000313|Proteomes:UP000255382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC5050 {ECO:0000313|EMBL:STU59530.1,
RC   ECO:0000313|Proteomes:UP000255382};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC       family. {ECO:0000256|ARBA:ARBA00009617}.
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DR   EMBL; UGLZ01000004; STU59530.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A377Z1W4; -.
DR   Proteomes; UP000255382; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   CDD; cd17332; MFS_MelB_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR039672; MFS_2.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001927; Na/Gal_symport.
DR   InterPro; IPR018043; Na/Gal_symport_CS.
DR   NCBIfam; TIGR00792; gph; 1.
DR   PANTHER; PTHR11328:SF24; INNER MEMBRANE SYMPORTER YICJ-RELATED; 1.
DR   PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13347; MFS_2; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000255382};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        43..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        83..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        112..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        308..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   436 AA;  47661 MW;  9FA509B6603FB9B8 CRC64;
     MNHDNKLSFA EKLGYGMGDA ACGIVYSSVT MFLTWFYTDI YGLSAAAVGV MFLVTRVLDA
     ITDPLTGIVA DRVKTRWGHF RPWLIWFAVP YAVLAVMTFT TPEFGASGKL VYAYLTYTLL
     MLCYTFINIP YCALGGVITR DEKDRLSAQS YRFTISSLAG LMVSVATLFL VDFFGKENKQ
     FGFQATMGIM GAIAIVMLAF CFFSTKERVA PAVEQQGSIR EDLRQLLAND QWRIVAIITF
     FSSMAGVMRS AATLYYATYL MLGGVESAAG TAMKSAFVST SVVGTIIGSI AAGWLAKRYR
     AVSLFKNINL LLVLVGVVMF FVPPTWLPVV FPLYFLVGFF HQMYQPFKWN MMANAADYGE
     WKFGRRITGL SYSGNLFALK MGMAVAGAAV GFSLGLFGYQ AGVTAQTPLA TMGIVGLLTL
     RSITILPAPV VAGAFL
//