ID A0A378C3S1_KLEPO Unreviewed; 308 AA.
AC A0A378C3S1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288};
DE EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288};
GN Name=hemE_1 {ECO:0000313|EMBL:STV60652.1};
GN ORFNames=NCTC5050_06916 {ECO:0000313|EMBL:STV60652.1};
OS Klebsiella pneumoniae subsp. ozaenae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=574 {ECO:0000313|EMBL:STV60652.1, ECO:0000313|Proteomes:UP000255382};
RN [1] {ECO:0000313|EMBL:STV60652.1, ECO:0000313|Proteomes:UP000255382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC5050 {ECO:0000313|EMBL:STV60652.1,
RC ECO:0000313|Proteomes:UP000255382};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00004804}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00009935}.
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DR EMBL; UGLZ01000005; STV60652.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A378C3S1; -.
DR UniPathway; UPA00251; UER00321.
DR Proteomes; UP000255382; Unassembled WGS sequence.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00717; URO-D; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; TIGR01464; hemE; 1.
DR PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
DR PROSITE; PS00907; UROD_2; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:STV60652.1};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000255382}.
FT DOMAIN 96..112
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
SQ SEQUENCE 308 AA; 33755 MW; FAE3D02EBCB07D81 CRC64;
MSLCKNAELA CEVTLQPLRR YPLDAAILFS DILTIPDAMG LGLYFEAGEG PRFTSPVKSK
ADVDKLPIPD PEQELGYVMN AVRTIRRELK GEVPLIGFSG SPWTLATYMV EGGSSKAFTV
IKKMMYAEPQ ALHALLDKLA KSVTLYLNAQ IKAGAQSVMI FDTWGGVLTG RDYQQFSLYY
MHKIVDGLLR ENEGRRVPVT LFTKGGGQWL EAMAETGCDA LGLDWTTDIA DARRRVGNKV
ALQGNMDPSL LYASAPRIEE EVATILAGFG QGEGHVFNLG HGIHQDVDPE HAGVFVEAVH
RLSAPYHQ
//
