ID   A0A378I3D7_9GAMM        Unreviewed;      1084 AA.
AC   A0A378I3D7;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:STX29280.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:STX29280.1};
GN   Name=cyaB {ECO:0000313|EMBL:STX29280.1};
GN   ORFNames=NCTC13315_01819 {ECO:0000313|EMBL:STX29280.1};
OS   Legionella beliardensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=91822 {ECO:0000313|EMBL:STX29280.1, ECO:0000313|Proteomes:UP000254968};
RN   [1] {ECO:0000313|EMBL:STX29280.1, ECO:0000313|Proteomes:UP000254968}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13315 {ECO:0000313|EMBL:STX29280.1,
RC   ECO:0000313|Proteomes:UP000254968};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UGNV01000001; STX29280.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A378I3D7; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000254968; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR025874; DZR.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF12773; DZR; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:STX29280.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000254968};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   TRANSMEM        911..936
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          74..199
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1084 AA;  122152 MW;  B42E4417E09154B2 CRC64;
     MYCNQCHFIL QEQKFCPQCG TPTRVTKTCP NCHKECSLDS NFCGECGTSL VTQPKPIQPM
     ANRKDSEAIK KHVSILFADI KESTSAISNL DPEEARNLLS PAIEKMLNAV YQYSGTIIHT
     AGDGIVAIFG APQALEDHAF RACLAANFMQ TQLNALPLGL KIRVGLNSGE ILMDVVGRSE
     QHLEYDITGA AVNLAARMEQ TATPGNIQIT KHTLILVKDA VEVESIGRIT IKGFSEPVEV
     FKLKGIKDES NLISLKYRPT FTPFVGRNDT IKKLNELLDL AEAGQGSMVC LEAEAGQGKS
     RVIYELLNNN TSLQIIYSGG FSHLCNVTLF PIVQLFRKLL DIHQDDLTEN IYDKVCPYTK
     DLTVPYATDA ALSLLNSSGY SKAWEKLAPQ LKHKYLFLIG IAILTKACTN KTLVLIIEDL
     HWIDNETENF ISLLLNEIHK LKILLIGTYR PSFNDTWLKN PNYHLIKLGP IPQKHLKTLA
     DIILGTHPSI NSLKKDILHA CSGNPFFIQE IIDSLIADNL LTGRLGNYQL DTVNFAKRSK
     LPESIFALLQ TKIDKLPAHQ KELLEIASVI GERFPYTLIA QLSTTENKVT RKNLNQLTAL
     NYIYEAQLYP DLEFSFSHAL IQEVLYNTLL KKVRHQIHLK ILEFFECLPE DQKKEKIQIL
     ANHAYLGQHW EKAFYYCAQA AEKTFIINAL KLTIQYSKQA IEAAAYIKDQ SSIIDSLIMV
     HIDMMHAYLH LGLPEEQGPI LEKILKLSVE AKRPAVKCAV YGAYATFIMG ISCPQHAEPF
     LEKANQYAKE SKRQDLMKFV DFAFLLRYTL GGDYIKGQKI GRTFLAQQAS QDFFCPEFRL
     NFRYVGIIIL MINQLTSGAF LDFDRQIEFY STCFNLTEPS IYSAGITTAL GTALVQKGDF
     SSTAERYLHL AIYYLIEVNF FLILPLAQAA LALLYLNTKR LKEGKEQLEK AQNSIELVGY
     YLSSNYSVGF IAEGLLLSGQ LTKADKFIQN ALALSEKRNL KGNMAWLKRL SAEIALKKSK
     LNPLKIKNLL EEALILTKET HMKIQEGKCH LTLAKYYQIS KHNEMAVKEE KLAYAIFKQI
     GYKL
//