ID A0A378UG90_BERDE Unreviewed; 296 AA.
AC A0A378UG90;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=3-hydroxyacid dehydrogenase {ECO:0000313|EMBL:STZ76394.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:STZ76394.1};
GN Name=garR_1 {ECO:0000313|EMBL:STZ76394.1};
GN ORFNames=NCTC10295_01158 {ECO:0000313|EMBL:STZ76394.1};
OS Bergeriella denitrificans (Neisseria denitrificans).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Bergeriella.
OX NCBI_TaxID=494 {ECO:0000313|EMBL:STZ76394.1, ECO:0000313|Proteomes:UP000254651};
RN [1] {ECO:0000313|EMBL:STZ76394.1, ECO:0000313|Proteomes:UP000254651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10295 {ECO:0000313|EMBL:STZ76394.1,
RC ECO:0000313|Proteomes:UP000254651};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UGQS01000002; STZ76394.1; -; Genomic_DNA.
DR RefSeq; WP_066076585.1; NZ_UGQS01000002.1.
DR AlphaFoldDB; A0A378UG90; -.
DR Proteomes; UP000254651; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR HAMAP; MF_02032; Tartronate_sem_reduc; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006398; Tartro_sem_red.
DR NCBIfam; TIGR01505; tartro_sem_red; 1.
DR PANTHER; PTHR43060:SF3; 2-HYDROXY-3-OXOPROPIONATE REDUCTASE; 1.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:STZ76394.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000254651}.
FT DOMAIN 2..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 296 AA; 31120 MW; E3AB79FFC25D5122 CRC64;
MKIGFIGLGI MGKPMSKNLL KAGHELVVLD TKKEAVDELV AAGAKSAATP KEVAQQVDAV
ITMLPNSPHV KTVVLGENGV IEAAREGLAV IDMSSIAPLA SREIYEELAE KGVEMLDAPV
SGGEPKAIDG TLSVMVGGKK EVFDKYFDVM KAMAGSVVYT GDIGAGNVTK LANQVIVALN
IAAMSEALVL ATKAGVDPEL VYQAIRGGLA GSTVLDAKAP MVLDRNFKPG FRIDLHIKDL
ANALDTSHGV GASLPLTAAV MEMMQVLKLD GHGQEDHSAL ARYYEKLTNS EVKRSN
//