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Database: UniProt
Entry: A0A378UG90_BERDE
LinkDB: A0A378UG90_BERDE
Original site: A0A378UG90_BERDE 
ID   A0A378UG90_BERDE        Unreviewed;       296 AA.
AC   A0A378UG90;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=3-hydroxyacid dehydrogenase {ECO:0000313|EMBL:STZ76394.1};
DE            EC=1.1.1.60 {ECO:0000313|EMBL:STZ76394.1};
GN   Name=garR_1 {ECO:0000313|EMBL:STZ76394.1};
GN   ORFNames=NCTC10295_01158 {ECO:0000313|EMBL:STZ76394.1};
OS   Bergeriella denitrificans (Neisseria denitrificans).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Bergeriella.
OX   NCBI_TaxID=494 {ECO:0000313|EMBL:STZ76394.1, ECO:0000313|Proteomes:UP000254651};
RN   [1] {ECO:0000313|EMBL:STZ76394.1, ECO:0000313|Proteomes:UP000254651}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10295 {ECO:0000313|EMBL:STZ76394.1,
RC   ECO:0000313|Proteomes:UP000254651};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UGQS01000002; STZ76394.1; -; Genomic_DNA.
DR   RefSeq; WP_066076585.1; NZ_UGQS01000002.1.
DR   AlphaFoldDB; A0A378UG90; -.
DR   Proteomes; UP000254651; Unassembled WGS sequence.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   HAMAP; MF_02032; Tartronate_sem_reduc; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006398; Tartro_sem_red.
DR   NCBIfam; TIGR01505; tartro_sem_red; 1.
DR   PANTHER; PTHR43060:SF3; 2-HYDROXY-3-OXOPROPIONATE REDUCTASE; 1.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000313|EMBL:STZ76394.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000254651}.
FT   DOMAIN          2..161
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          164..284
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        170
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   296 AA;  31120 MW;  E3AB79FFC25D5122 CRC64;
     MKIGFIGLGI MGKPMSKNLL KAGHELVVLD TKKEAVDELV AAGAKSAATP KEVAQQVDAV
     ITMLPNSPHV KTVVLGENGV IEAAREGLAV IDMSSIAPLA SREIYEELAE KGVEMLDAPV
     SGGEPKAIDG TLSVMVGGKK EVFDKYFDVM KAMAGSVVYT GDIGAGNVTK LANQVIVALN
     IAAMSEALVL ATKAGVDPEL VYQAIRGGLA GSTVLDAKAP MVLDRNFKPG FRIDLHIKDL
     ANALDTSHGV GASLPLTAAV MEMMQVLKLD GHGQEDHSAL ARYYEKLTNS EVKRSN
//
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