ID A0A378Y9K0_9NOCA Unreviewed; 1372 AA.
AC A0A378Y9K0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Multidrug export ATP-binding/permease protein SAV1866 {ECO:0000313|EMBL:SUA73057.1};
DE EC=3.6.3.- {ECO:0000313|EMBL:SUA73057.1};
GN ORFNames=NCTC1934_00491 {ECO:0000313|EMBL:SUA73057.1};
OS Nocardia otitidiscaviarum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1823 {ECO:0000313|EMBL:SUA73057.1, ECO:0000313|Proteomes:UP000255467};
RN [1] {ECO:0000313|EMBL:SUA73057.1, ECO:0000313|Proteomes:UP000255467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC1934 {ECO:0000313|EMBL:SUA73057.1,
RC ECO:0000313|Proteomes:UP000255467};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UGRY01000002; SUA73057.1; -; Genomic_DNA.
DR STRING; 1406858.GCA_000710895_01481; -.
DR Proteomes; UP000255467; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18543; ABC_6TM_Rv0194_D1_like; 1.
DR CDD; cd18546; ABC_6TM_Rv0194_D2_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221:SF658; ABC TRANSPORTER B FAMILY MEMBER 29, CHLOROPLASTIC; 1.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:SUA73057.1};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Hydrolase {ECO:0000313|EMBL:SUA73057.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000255467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1042..1060
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..283
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 317..555
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 792..1074
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1110..1349
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 529..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1372 AA; 145115 MW; 7E974F52DA871D1F CRC64;
MLLGITAALL AGAVVEVTGP LLAKRALDGA TAGDTAIIGV MAGFMAVLAV GRFAATFTRR
WLAGRLALDV QHELRLDLLA ALQRLDGRGQ DALRTGQVVS RSITDLQLVQ GLLAMAPWST
MAALQFVLAA AVMLWLSPPL ALTALLVVPA IAVVVYRIRP RLYAATWSAQ QRAADLAQHV
EETVTGVRVV KGFGQESRMV GVLEGHGRRL FAERMRAARL DARFAPTLAA IPQAGLVGVI
AVGGLLALRG SIGVGTFLAF TAYVATMTAA ARTISSVLVM AQLTRAAAER VHQVIDSAPL
RTDPEHPVAL PSGPLGIEID GLSFGFDPEQ PILRDFTLTV EPGETVAIIG PAGSGKSTLA
LLLPRFYPPD AGRIMLRGGD TRADLAELRA ADLRSAIGVV FDEPFLFSDT IAANIALGRP
DATAAEIRAA ADIAAAAEFI ETLPEGYDTV VGERGLTLSG GQRQRIALAR ALLTDPRILV
LDDATSAVDA VTEAAIFDAL PHRAGRTTII LAHRESTLAR ADRVIRLPGP DLTVPSGIVA
EGHEEPGNGH HEQRREPEHP QPHDRPVAHP QPGEHDEQQH EHPVERGPLG MSSHASGVLP
APAERQYARS DHRSRGNGHD TDHRASTEPP HHESLPATDH RPVTTTEQPP TEPRAHGGSP
HGEPAPASDP PDGRVDVSSG RQSPTATPTD SGPHVGAAGS DSSHHSDTSS PGREHHVSTA
ADGGPDPDAV SVGHGAAGPT QLDPDTPPEV RRSLRKLAPA TELPGVDERG LREPDPGFRL
RRALRPVRWL VAATVLLLGL DALVSVGFPS LVRFAIDHGV SAGNGGALGW AAGGGAVLVA
VGWVVASAAL LWGSRAGERV LYGLRVRSYA HLQRLGLDYY ERELSGRIMT RMTTDIDALS
TFLQTGVPEV VVSLLTVVGI AAALLLIDAQ LALVIIAAIP PLALATWLFR RVSNSAYSAA
REHAATVNAD FQENVSGLRV VQAYRHEPRA ARRFARYSDN YRASRMRAQR AIAVFFSFVG
AWTDLALAAV VFAGAWQVAR GTTTAGTLVA FVLYLGLLFG PIHQLSQLFD GYQQARVGLR
RIGELLRTES SIAADPENAV PIAGELRGEV VFENVRFRYP TASTPALDGV SFRIPAGGSL
ALVGATGAGK STIVKLLARL YDLPRDPDSG GVFVDGVDIR DYRLTDYRSR LGVVPQEAHL
FTGDVASNIS FGKPFATTSQ IARAADEVGA LDTIAALPRG FGQPVGERGR GLSAGQRQLI
ALARAELVHP DLLLLDEATA VLDPAAEASV LVASRSVTRG RTAIIVAHRL ATAAQADRIA
VVEHGRITEI GTHDELLAAA GTYSRLWAAA GAEKGIFSGG DESSPREMST RW
//
