UniProt: A0A378YB01

Database: UniProt
Entry: A0A378YB01_9NOCA

LinkDB:  A0A378YB01_9NOCA 
Original site:  A0A378YB01_9NOCA

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Ontology (5)   
   GO (5)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (9)   
   InterPro (6)   
   Pfam (2)   
   SMART (1)   
All databases (19)   

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ID   A0A378YB01_9NOCA        Unreviewed;       285 AA.
AC   A0A378YB01;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000256|HAMAP-Rule:MF_01131};
GN   Name=rex {ECO:0000256|HAMAP-Rule:MF_01131,
GN   ECO:0000313|EMBL:SUA73691.1};
GN   ORFNames=FOH10_34575 {ECO:0000313|EMBL:QDP83084.1}, NCTC1934_01138
GN   {ECO:0000313|EMBL:SUA73691.1};
OS   Nocardia otitidiscaviarum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1823 {ECO:0000313|EMBL:SUA73691.1, ECO:0000313|Proteomes:UP000255467};
RN   [1] {ECO:0000313|EMBL:SUA73691.1, ECO:0000313|Proteomes:UP000255467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC1934 {ECO:0000313|EMBL:SUA73691.1,
RC   ECO:0000313|Proteomes:UP000255467};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:QDP83084.1, ECO:0000313|Proteomes:UP000317039}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEB252 {ECO:0000313|EMBL:QDP83084.1,
RC   ECO:0000313|Proteomes:UP000317039};
RA   Fomenkov A., Anton B.P., Vincze T., Roberts R.J.;
RT   "Complete Genome Sequence and Methylome Analysis of Nocardia otitidis-
RT   caviarum NEB252.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates transcription in response to changes in cellular
CC       NADH/NAD(+) redox state. {ECO:0000256|HAMAP-Rule:MF_01131}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01131}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01131}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000256|HAMAP-Rule:MF_01131}.
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DR   EMBL; CP041695; QDP83084.1; -; Genomic_DNA.
DR   EMBL; UGRY01000002; SUA73691.1; -; Genomic_DNA.
DR   RefSeq; WP_029926077.1; NZ_UGRY01000002.1.
DR   AlphaFoldDB; A0A378YB01; -.
DR   STRING; 1406858.GCA_000710895_05574; -.
DR   GeneID; 80337479; -.
DR   KEGG; nod:FOH10_34575; -.
DR   OrthoDB; 9784760at2; -.
DR   Proteomes; UP000255467; Unassembled WGS sequence.
DR   Proteomes; UP000317039; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR   PANTHER; PTHR35786:SF1; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01131};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_01131}; NAD {ECO:0000256|HAMAP-Rule:MF_01131};
KW   Reference proteome {ECO:0000313|Proteomes:UP000255467};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_01131};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_01131};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_01131}.
FT   DOMAIN          93..194
FT                   /note="CoA-binding"
FT                   /evidence="ECO:0000259|SMART:SM00881"
FT   DNA_BIND        30..69
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01131"
FT   BINDING         104..109
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01131"
SQ   SEQUENCE   285 AA;  29734 MW;  E36391F7E3CD1EEC CRC64;
     MTEQHETPGG VSGRALQKDI PQATVARLAT YLRVLAVLAD EGTAIVSSEE LAVAAGVGSA
     KLRKDLSFLG PNGVRGVGYD VIKLRDRIED VLGLSEGHRV VLVGAGNLGR ALIGYGGFRR
     RGFSMVGIFD NDPAVIGTTV SGLPIRDVAE LPRAIGLLEP TIAVITVPDA AAQGVCDLLV
     EAGMQSILSF SPVALDAPDA VEVRRVDLAV EMQLLSFERA RNAELEAAES EVAAGETVGA
     DTVRAAADAA LERTVHTAER GTRRVTPIQT SHAAMEPTKG SVVTP
//

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