ID A0A378YB54_9NOCA Unreviewed; 390 AA.
AC A0A378YB54;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:SUA74314.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:SUA74314.1};
GN Name=thlA_2 {ECO:0000313|EMBL:SUA74314.1};
GN ORFNames=NCTC1934_01523 {ECO:0000313|EMBL:SUA74314.1};
OS Nocardia otitidiscaviarum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1823 {ECO:0000313|EMBL:SUA74314.1, ECO:0000313|Proteomes:UP000255467};
RN [1] {ECO:0000313|EMBL:SUA74314.1, ECO:0000313|Proteomes:UP000255467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC1934 {ECO:0000313|EMBL:SUA74314.1,
RC ECO:0000313|Proteomes:UP000255467};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; UGRY01000002; SUA74314.1; -; Genomic_DNA.
DR RefSeq; WP_039818144.1; NZ_UGRY01000002.1.
DR AlphaFoldDB; A0A378YB54; -.
DR STRING; 1406858.GCA_000710895_02995; -.
DR OrthoDB; 3204099at2; -.
DR Proteomes; UP000255467; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:SUA74314.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000255467};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SUA74314.1}.
FT DOMAIN 5..258
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 267..387
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 345
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 375
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 390 AA; 40590 MW; 9BDEF3E35E1A2A64 CRC64;
MRDAVIVEAV RTPVGKGKPT GALHGVHPVD LLAHSLREVV ARSGIDPELI DDVIGGVVTA
VGEQGSNLTR RAALAAGFPE SVPATTVDRQ CGSSQQAIHF AAQGVIAGAY DIVVAAGVES
MSRVPMGANL IGAEDVTGVG FAERYPEGLV PQGISAELIA ARWNLGRTQL DEFALSSHEK
AARATKDGSF DAQLAPLAGL TADEGIRLGS TLETLSGLRP AYYSEAMAAR FPEIDWNITA
ANASQINDGS SAVLIMTSER AAQLGLRPLA RVHSFAVAGD DPLLMLTAVI PATRKVLHRA
GLQLSDIDLF EVNEAFSSVV LAWAHDTGAD LAKVNVNGGA IAIGHPLGAS GGRLATTLVH
AMHDHGARWG LQTMCEAGGL ANATIYERIR
//
