ID A0A379CCC2_9PAST Unreviewed; 346 AA.
AC A0A379CCC2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=lipopolysaccharide heptosyltransferase II {ECO:0000256|ARBA:ARBA00044042};
DE EC=2.4.99.24 {ECO:0000256|ARBA:ARBA00044042};
GN Name=rfaF {ECO:0000313|EMBL:SUB59808.1};
GN ORFNames=NCTC12872_01855 {ECO:0000313|EMBL:SUB59808.1};
OS Phocoenobacter uteri.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Phocoenobacter.
OX NCBI_TaxID=146806 {ECO:0000313|EMBL:SUB59808.1, ECO:0000313|Proteomes:UP000255417};
RN [1] {ECO:0000313|EMBL:SUB59808.1, ECO:0000313|Proteomes:UP000255417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12872 {ECO:0000313|EMBL:SUB59808.1,
RC ECO:0000313|Proteomes:UP000255417};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-
CC [alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-
CC (1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid
CC A + H(+); Xref=Rhea:RHEA:74071, ChEBI:CHEBI:15378, ChEBI:CHEBI:61506,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:193069, ChEBI:CHEBI:456216;
CC EC=2.4.99.24; Evidence={ECO:0000256|ARBA:ARBA00043830};
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
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DR EMBL; UGTA01000001; SUB59808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A379CCC2; -.
DR OrthoDB; 9797795at2; -.
DR Proteomes; UP000255417; Unassembled WGS sequence.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011910; RfaF.
DR NCBIfam; TIGR02195; heptsyl_trn_II; 1.
DR PANTHER; PTHR30160:SF7; ADP-HEPTOSE--LPS HEPTOSYLTRANSFERASE 2; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000255417};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SUB59808.1}.
SQ SEQUENCE 346 AA; 39334 MW; 2C3EC6A6FD53A3FC CRC64;
MNILIIGPSW VGDMMMSHSL YQQLKKNYPN CQIDVMAPDW CRPLLSRMPE IRKAITMPLG
HGAFELRKRY DLGKDLQNQY DMAIVLPNSL KSAFIPFFAK IPVRRGWKGE MRYGLLNDLR
NNKNDYPMMV QRYVALAYEK GRIPNAEKIK IDYPYLSVEK QQVEQTLTQF EKQFAYAENR
ETIGFCPGAE FGPAKRWPHY HYAKLAQLLI ERGYSITIFG SAKDNTVGEE IRTALSEEQQ
RYCINLAGQT NLNQAVDLIS TCRAVVSNDS GLMHIAAALG KPLVALYGPT SPQYTPPLSE
KVKIIRLIEG GLIKVRKGDA EQGYHQSLID IQPETVLSEL DKLLTE
//
