ID   A0A379JGH2_9NOCA        Unreviewed;      4506 AA.
AC   A0A379JGH2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Linear gramicidin synthase subunit D {ECO:0000313|EMBL:SUD47632.1};
GN   Name=lgrD_7 {ECO:0000313|EMBL:SUD47632.1};
GN   ORFNames=NCTC1934_04953 {ECO:0000313|EMBL:SUD47632.1};
OS   Nocardia otitidiscaviarum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1823 {ECO:0000313|EMBL:SUD47632.1, ECO:0000313|Proteomes:UP000255467};
RN   [1] {ECO:0000313|EMBL:SUD47632.1, ECO:0000313|Proteomes:UP000255467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC1934 {ECO:0000313|EMBL:SUD47632.1,
RC   ECO:0000313|Proteomes:UP000255467};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; UGRY01000003; SUD47632.1; -; Genomic_DNA.
DR   RefSeq; WP_051037016.1; NZ_UGRY01000003.1.
DR   STRING; 1406858.GCA_000710895_02072; -.
DR   OrthoDB; 5475787at2; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000255467; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd19540; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000255467}.
FT   DOMAIN          976..1050
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2557..2632
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3602..3677
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4161..4236
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          596..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1974..2051
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4506 AA;  477802 MW;  85B78F396F302558 CRC64;
     MTREVTAQAT ATVFPLSPAQ SGMWYAQQLD PSVPLSEAQY IEMRGPLDRE RLRTAAITAA
     REFGSGVLRL VEIDGEPHQV VDPGLETAVG YLDLSGRPDP MAAALEWMRA EVAEPIDLLG
     DRVGMTVVLK VGADHHLWYS RAHHILIDGF GSVSMLYRVA ELYNAATRGE SAPPSSAASL
     LEVHEAEVAY RNSSRYRADQ RYWREIVAGM PDRCSLVSAT APACALAREQ RGELSPETAA
     RLEAAARRFD TSSATLVMAA LALYYARLTA MDEVVISLPV SGRTTALLRR SGGMIANVVP
     LRVPVPDRGT VGEVMEALRV AASGALRHQR FRHEDMRDGA EDQPEFGRGL VGPVVNIMLF
     PRGIDFEGVE SSLHVLTSGP IEDLFVNFYQ HGADAPIHVD FAANPRLYDE DSLGRHHGRF
     LTLLESLLDT APATPLSELA YRGPADEAVS RGAFGPRPPR PRLLPDILRD GLRRAGRDAV
     AVVSGNRRLT YGELDARSDR LAHRLIAAGA ATGVRVGPET PVLLALPRSV AAVVAVWAVT
     KTGAAFVPLG TALPGDRVLR IAGECDARLG LTVAETLPGL PGSVGWLVLE ADSGEPVEVA
     GDGPEPQSRG PRGVESPWPL PHARIDNPAY LVFTSGSTGV PKGVVVTHRG LAGLAAAIVD
     AYDVTPGSRV LQSLNPSFDA AVLEWLQAFA AGATLVVADA DPVLGGDMAR IVREYGVTQV
     CSTPAVLATL DPGALDGVRA VSTGGEPCPP ELVARFGPGR RLLNSYGPSE TTVAVTYTDA
     LLPGVPAGLG NPIPGVGVLV LDRLLRPVPI GVVGELYVAG AGVARGYAGR PGLTAQRFVA
     APSGERVYRT GDLVRWTAPG VLEYVGRGDF QVKLRGMRIE LGEIDAVLDA HPGVEIAVTV
     ARPVGAGTAL ASYVVPVAGA RIGEPELLEH AARRLPPYMV PATVTVLGAL PLTGNGKVDR
     AALPEPVVAS PVRRRAAATE AERLLCELFG EVLGSGPVDP ESSFFALGGD SIMAIGLVSR
     ARAAGLVFSA RDVFERRTPA ALAAAAHRTS DGPRRLPELP GGGVGRMPLT PIAAWLLARP
     GWERFAQSMV VRLPIGIEPA ALARRVQGLL DRHDMLRARV VESVTGPVLE VPPPQVADAE
     RLLTRVPCGD PDLRVDCELA EAVRRLDPRG GRMLALTWLD PGPAASGRLI VAAHHLACDA
     VSWRILLPDL MTAWSRTCTG HAADLPGTGT SVRTWAHVLH ALAVDEDADG LPEGFADRFG
     GLEHWRAVLA PDPVLGRRRL DPAVDTHRTA GRIRVELPEA ETEVLLTRVA AAYRCGVEEA
     LLAGLVLALA RFRARRGRPD AETVVTVERH GRDEAVAPGA ELSRTVGWFT RQVPLRIGPA
     AETVAAVVKT VKEQVRSVPA GGVGYGLLRY LNPAGGDLAA LPEPQIGFNY LGQIPGAAVE
     ADWMPVGMTD RLGGHAHPDM PLAAVVSVDA AALVTERGTR LHAVWQYACV AIDHEAADEL
     AHDWLAAVTE IARRLTEPEA GGRTPSDLSL IATTQAEIDS WEARFGHLDD VWPLTPLQRG
     LLFQAQLAPD GLDGYSVQAV IDIEAELDRD RLTAAAAALV RRHPALRAAF VQTAETAVQV
     IVSDVEVPWT ELDAHGATDP ELDELAARQL RIPFEVDRPP LLRFACIALA PNRFRLVITN
     HHLILDGWSM PLLFGDLVAL YETGGSDTGF TEPPAPRHYL EWLAARPRDP ARAAWTSALA
     GLDGPTLAAP SAPRGEAATA PVAHEVPLPE GCAARLRRAA ADREVTVNTL VQVAWALLLA
     ELTGDTDIVF GATVSGRPPE LPGSDRMIGM LVNTVPVRIT LRPAESVTDL LTRVRAEQSA
     LAEHHTLGLD EIQALAGIGP LFDTATVFES YPVDAAALTA ATRQARLRVT GIRGHDGTHY
     PLALATYAGD GLRLVLSRSP RHFDADEAES MARALSRILT TLADGDNLRT AEIRGTADRG
     HTEWSGSPAL PPRLLPDLLT ATGSPDALAA TMTTPKPTVP ARRGEPVAGD FGRDGGAEPG
     SSGHATPGSN VHGGVGFGAT AVTYAQLDEL SNRLARLLIR AGAGPERTVL LALPRSVDQM
     IALWAVAKTG AAFVPVDCEQ PAARTAAIAA ECGAVLGISA AGADAALPDS VRWLLLDDPE
     TGAATAAVSG AAVDAAARLA PLRPEHPAYV VFTSGSTGTP KGVVVTHAGL VNLVAAAASN
     GRIGPDSRLL HALNPSFDAA ILVWLSAFAV GATLVIAPPE ASAGGELADS IATGAPTHLI
     CTPGVLATLR DEQLRGVATA IIGGEPCPPA LVARLGSTRA LVNSYGPAET SVAVSFGDPM
     TPDTAAIVGA PVPGATLLVL DRWLRPVPVG TVGELYVRGP GLARGYAGRT ALTASRFVAD
     PFTDGQRLYR TGDLVRYITP GNLEYVGRGD SQVKVRGIRV EPGEVDSALT AHPQVESAVT
     VARPTRAGTT ALCSYITFRT PTAAEPSLFA GSSVPLSGTG SSVPPSVTEL TAWLSARLPR
     YLVPSSITVL PELPRTASGK VDLRALPEPE APYTEYVAPT GTAAVVAATF AEVLHAERVG
     ARDDFFALGG DSLLAARVAA RLSAALRTAI PVRALFEAPV VADLARRLDT ATVAATAPPL
     VRGTRPDRIP LSPAQQRMWF VNRYDPTSPA YNIPLALRLS GDLDRTALRH ALSDVLERHE
     ALRTVYPDID GVGSQRIVAA AAVELDLTPI PVRAADIGAA VASAVGTGFD VTASVPLRLR
     LFRVEGTDDF VLVVVAHHIA LDGYSMTPLV RDVVTAYTAR VRGAAPAWQP LPVQYADYAL
     WQHTRLGAAD DPESLLHHQL RYWTEVLADA PDQLDLPTDR PRPARASHRA AEVSDRLDAD
     LTAAVDHCAR TWRATPFMVL HAALSILLAR LSGARDVVIG TPIAGRGDRE LDDLVGMFVN
     TLALRTDIRA EEGFGALLER VRRTDLDAFG HADLPFERLV EELAPARSAA RHPITQVMLV
     FQNLTHPEFT LPGLRVAPLE LPRTVSRFDL SLTVSGGADG MELRCDYATD LFDATTVRML
     LRRLVRLLTA VTADPARPVG DIELCTETEL RHLRTHTPPV ATPRPLADLL AEAVAANPDG
     VAVRCADRQL TYRELDARAE RLARQLTRAG AGPETVVAVG IPRSLESVLA VWAVTRTGAA
     FVPVDPSYPP ERIAHIIDTA GVRLGLTVPA CRDRLPATVH WWNLDSRYPD DADIGPTAAE
     QHRPPPRIRP EHPAYVLFTS GSTGAPKGVM VTHAGLANMA AAQRKRCHLT SDSRVLHVAS
     PSFDASVLEL IMAAGAAATL VVAPPTVFAG SELADLLARE RVSHIALTPS ALATVDPAGL
     DALQVIINGG EPCPPELVAA WSAPGRAHYN DYGPTEATVW ATGSAALHPG DTVTIGTPAP
     GVRAVILDTR LRPVPDGVVG ELYLSGITLA RGYLGRGDLT AARFVADPYG AAGERMYRTG
     DLVRRRGTEL EYLGRTDNQV KLRGLRIELG EVEAALTADP AVAHAVAVVR ADGRGDALVA
     YVLGAAGPPD VAQLKRAVAQ RLPSYMVPSA IVALDSLPRT ANGKLDLDAL PAPQHTAAER
     RAPETAAERA VATAFQEVLA VERVWLDDDF FALGGNSLIA TRVVARLGAA LDAAVPVRAL
     FDAPTVAELA ELVTSGTTSG RTRPGPRSRP ERIPLSAAQR RMWFLNRYDP ESPAYNIPAA
     FDITGALDVS ALRAALDDVV ARHEILRTRY PVDADGLPRQ EILAPAPGMT PVRELEVAAD
     ELDDMLAARL SRGFDLTRET PLRVWVLRLA PEHAVLAMAV HHIAADGWSM GPLARDVLAA
     YASRLSGEPP RWTPLPLQYA DYALWQHDLL GAADDPAGLA HRQLEFWRTT LDGLPERHTI
     PTDRPRPATP SGSGDRIAFT IPAEVHDRVH VLSRAVGASP FMVAHTALAV LLARLSGVPD
     IAIGSVVAGR GDGELDDLVG MFVNTVVLRS HLDPALSFTA ALSDTRRADL AAYGNLDLPF
     EQVVEALAPT RDTAHHPLFQ VLLAFQNLPP AATALPGLHI RPLDTAAPGA KFDLEWMLAE
     HFGPAGEPAG ITGSLIFATD LFDRTTAQTM ADGLERLIEA ATTAPESTLA ELTGWSGAAT
     ATAVPTVHGR PEPVPPRPYR APRTELERLV VDAFEAVLEN PRIGVDDNFF DHGGNSMAAV
     RLAERLGAST GNAVPLHLVF AAPTPAALAR RLSESTPDSA ADILLPLRST GTAPALFCLH
     PAIGLAWCYA GLVRYIDPAR PVHGIQSPGI PDGGTVGDLA TRYADEIQRT QPHGPYHLLG
     YSAGGLLAHA VAVELRRRGA PVPSLIMMDA RADVEVTDDR MPAPELLLAE FGGVDVPEGV
     ALTAERAADL LHSTTGAASA LTAADLDRLY RDLRHLLHRI GAHRPEVFDG DVLFFTAAAG
     PPEPNVDTWI PHVDGEIHEV TLDFEHNRLI TPEALADIGP RVDAYLAGHR SPSAPARLST
     RRISGR
//