ID   A0A379JJR8_9NOCA        Unreviewed;       289 AA.
AC   A0A379JJR8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:SUD48636.1};
DE            EC=1.1.1.60 {ECO:0000313|EMBL:SUD48636.1};
GN   Name=garR_5 {ECO:0000313|EMBL:SUD48636.1};
GN   ORFNames=NCTC1934_05973 {ECO:0000313|EMBL:SUD48636.1};
OS   Nocardia otitidiscaviarum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1823 {ECO:0000313|EMBL:SUD48636.1, ECO:0000313|Proteomes:UP000255467};
RN   [1] {ECO:0000313|EMBL:SUD48636.1, ECO:0000313|Proteomes:UP000255467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC1934 {ECO:0000313|EMBL:SUD48636.1,
RC   ECO:0000313|Proteomes:UP000255467};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
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DR   EMBL; UGRY01000005; SUD48636.1; -; Genomic_DNA.
DR   RefSeq; WP_039814322.1; NZ_UGRY01000005.1.
DR   AlphaFoldDB; A0A379JJR8; -.
DR   STRING; 1406858.GCA_000710895_04645; -.
DR   OrthoDB; 4029976at2; -.
DR   Proteomes; UP000255467; Unassembled WGS sequence.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR048666; RedAm-like_C.
DR   PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   Pfam; PF21761; RedAm-like_C; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:SUD48636.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000255467}.
FT   DOMAIN          9..157
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          164..289
FT                   /note="NADPH-dependent reductive aminase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21761"
SQ   SEQUENCE   289 AA;  30204 MW;  9817D7923C785212 CRC64;
     MADNQHTPVT VLGLGAMGSA LAGALLKGGR ATTVWNRSAG KAAELVARGA TEAASVAEAV
     RAGEVIIAVL LDHASVHEQL DPVVAELRGK QLINLTSTAP AESRELARWA AAHGIDFLDG
     GIMAIPPMIG QPGSALLYSG SQAVFDRHRE TLELFGSVEY FGTDAGMAAL FDFALLANMY
     AMFGGFFHAA AMVGSAGVSA EEFGHRAQAW LTAMAHGLPE FGRTIDSGDF RAEVQQLAFQ
     KAAVDAIARA SRDAGVAPDV IAPLRNLIDR QVADGNGALA FEHTITQLR
//