ID A0A380K0G5_9STRE Unreviewed; 327 AA.
AC A0A380K0G5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=type I site-specific deoxyribonuclease {ECO:0000256|ARBA:ARBA00012654};
DE EC=3.1.21.3 {ECO:0000256|ARBA:ARBA00012654};
GN Name=hsdR_5 {ECO:0000313|EMBL:SUN58235.1};
GN ORFNames=NCTC12224_00264 {ECO:0000313|EMBL:SUN58235.1};
OS Streptococcus hyointestinalis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1337 {ECO:0000313|EMBL:SUN58235.1, ECO:0000313|Proteomes:UP000254924};
RN [1] {ECO:0000313|EMBL:SUN58235.1, ECO:0000313|Proteomes:UP000254924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12224 {ECO:0000313|EMBL:SUN58235.1,
RC ECO:0000313|Proteomes:UP000254924};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of DNA to give random double-stranded
CC fragments with terminal 5'-phosphates, ATP is simultaneously
CC hydrolyzed.; EC=3.1.21.3; Evidence={ECO:0000256|ARBA:ARBA00000851};
CC -!- SIMILARITY: Belongs to the HsdR family.
CC {ECO:0000256|ARBA:ARBA00008598}.
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DR EMBL; UHFN01000005; SUN58235.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A380K0G5; -.
DR Proteomes; UP000254924; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009035; F:type I site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd22332; HsdR_N; 1.
DR Gene3D; 3.90.1570.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007409; Restrct_endonuc_type1_HsdR_N.
DR InterPro; IPR040980; SWI2_SNF2.
DR PANTHER; PTHR30195:SF16; TYPE I RESTRICTION ENZYME ENDONUCLEASE SUBUNIT; 1.
DR PANTHER; PTHR30195; TYPE I SITE-SPECIFIC DEOXYRIBONUCLEASE PROTEIN SUBUNIT M AND R; 1.
DR Pfam; PF04313; HSDR_N; 1.
DR Pfam; PF18766; SWI2_SNF2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:SUN58235.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000254924};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT DOMAIN 5..199
FT /note="Restriction endonuclease type I HsdR N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04313"
FT DOMAIN 257..322
FT /note="SWI2/SNF2 ATPase"
FT /evidence="ECO:0000259|Pfam:PF18766"
SQ SEQUENCE 327 AA; 37749 MW; 46E3134718C39C47 CRC64;
MAELESVLEQ KLIDQLCQGE SQWTYRPDIR TEEELWDNFR YILEQNNKAK LNDGRLTDSE
FAKIKNDLSH ASFYDAGKWL VGENGQVYVH VQRGNEPLHL LVLNNEHIAG GTSVYEVINQ
YQAFGEDDAR DRRFDVTLLI NGIPMIHIEL KNKDHSYMDG FHQIKKYIAE GKFRGLFSNV
QMFVISNGVD TKYFSAARDN ELNKKFLTGW IDHDNQPVPD FIDFAKAVLK IPEAHEMVTK
YIVLDNDKKK LLILRPYQIH AIEAMRDASK KGKSGFIWHT TGSGKTMTSY KATRNLLMDI
PSIEKTIFLI DRKDLDVQTK TRLSVLC
//
