ID   A0A380KWZ9_9STRE        Unreviewed;       449 AA.
AC   A0A380KWZ9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Regulatory protein MsrR {ECO:0000256|ARBA:ARBA00040752};
GN   Name=msrR {ECO:0000313|EMBL:SUN75654.1};
GN   ORFNames=NCTC13765_00086 {ECO:0000313|EMBL:SUN75654.1};
OS   Streptococcus massiliensis.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=313439 {ECO:0000313|EMBL:SUN75654.1, ECO:0000313|Proteomes:UP000254634};
RN   [1] {ECO:0000313|EMBL:SUN75654.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13765 {ECO:0000313|EMBL:SUN75654.1};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC       and teicoplanin, as well as the synthesis of virulence factors.
CC       {ECO:0000256|ARBA:ARBA00037178}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family.
CC       {ECO:0000256|ARBA:ARBA00006068}.
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DR   EMBL; UHFR01000005; SUN75654.1; -; Genomic_DNA.
DR   RefSeq; WP_018370797.1; NZ_UHFR01000005.1.
DR   AlphaFoldDB; A0A380KWZ9; -.
DR   STRING; 1123307.GCA_000380065_00114; -.
DR   OrthoDB; 9782542at2; -.
DR   Proteomes; UP000254634; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.630.190; LCP protein; 1.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   NCBIfam; TIGR00350; lytR_cpsA_psr; 1.
DR   PANTHER; PTHR33392; POLYISOPRENYL-TEICHOIC ACID--PEPTIDOGLYCAN TEICHOIC ACID TRANSFERASE TAGU; 1.
DR   PANTHER; PTHR33392:SF8; REGULATORY PROTEIN MSRR; 1.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000254634};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          192..366
FT                   /note="Cell envelope-related transcriptional attenuator"
FT                   /evidence="ECO:0000259|Pfam:PF03816"
FT   REGION          70..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  50866 MW;  C0EE20A4455C2977 CRC64;
     MSRETDNLTH HERKRLDYLY KNYHYLNSRE QEEYDYLNRK RAGLANFSEN PRESHHQSVD
     NLPRYQETNR QEELTENGLP VYPKNLSRSE RKKQRTQASS LQNLENDTIS KSAAPRKKIR
     IKRILKWLAL ALILLVLGMV LMFFKGLLTA HNNPNAKPAE TEVFNGQDTK DGTNILILGT
     DGRIGQSSEE TRTDSIMVLN VGNKDGKIKL VSFMRDILVN IDGVSYGSNY DQKLNAAYSI
     GEQNNHQGAE LVRQMLKDNF DIDIKYYAMV DFSTFATAID TLFPNGVKMN AQFSTVGGEK
     VSEVEVPDDL NMKDGVVPNQ TIKVGEQRMD GRTLLNYARF RKDDEGDFGR TRRQQEVITA
     IVQQVKDPTK LFTGSEALGK IFALTSTNVP YSFLLTNGLS VATSGQKGID RVTIPEYGDW
     VDAYDMYGGQ GLLIDFEAYK TKLAQLGLR
//