ID A0A380LLE6_9FIRM Unreviewed; 169 AA.
AC A0A380LLE6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Cytidine and deoxycytidylate deaminase family protein {ECO:0000313|EMBL:SUO03400.1};
DE SubName: Full=Cytidine deaminase {ECO:0000313|EMBL:RGD73284.1};
DE SubName: Full=dCMP deaminase family protein {ECO:0000313|EMBL:NME44585.1};
GN Name=ribD {ECO:0000313|EMBL:SUO03400.1};
GN ORFNames=DXC78_11405 {ECO:0000313|EMBL:RGD73284.1}, HF861_06750
GN {ECO:0000313|EMBL:NME44585.1}, NCTC11087_00261
GN {ECO:0000313|EMBL:SUO03400.1};
OS Faecalicoccus pleomorphus.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Erysipelotrichaceae; Faecalicoccus.
OX NCBI_TaxID=1323 {ECO:0000313|EMBL:SUO03400.1, ECO:0000313|Proteomes:UP000255523};
RN [1] {ECO:0000313|EMBL:SUO03400.1, ECO:0000313|Proteomes:UP000255523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11087 {ECO:0000313|EMBL:SUO03400.1,
RC ECO:0000313|Proteomes:UP000255523};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RGD73284.1, ECO:0000313|Proteomes:UP000260721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TF08-11 {ECO:0000313|EMBL:RGD73284.1,
RC ECO:0000313|Proteomes:UP000260721};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:NME44585.1, ECO:0000313|Proteomes:UP000540014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSM-383-APC-22F {ECO:0000313|EMBL:NME44585.1,
RC ECO:0000313|Proteomes:UP000540014};
RA Hitch T.C.A., Wylensek D., Clavel T.;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRSR:PIRSR006019-2};
CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC family. {ECO:0000256|ARBA:ARBA00006576}.
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DR EMBL; JABAFR010000014; NME44585.1; -; Genomic_DNA.
DR EMBL; QUSK01000032; RGD73284.1; -; Genomic_DNA.
DR EMBL; UHFX01000003; SUO03400.1; -; Genomic_DNA.
DR RefSeq; WP_022789827.1; NZ_UHFX01000003.1.
DR AlphaFoldDB; A0A380LLE6; -.
DR STRING; 1123313.GCA_000420345_00964; -.
DR GeneID; 77461255; -.
DR OrthoDB; 9788517at2; -.
DR Proteomes; UP000255523; Unassembled WGS sequence.
DR Proteomes; UP000260721; Unassembled WGS sequence.
DR Proteomes; UP000540014; Unassembled WGS sequence.
DR GO; GO:0004132; F:dCMP deaminase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006220; P:pyrimidine nucleotide metabolic process; IEA:InterPro.
DR CDD; cd01286; deoxycytidylate_deaminase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR016473; dCMP_deaminase.
DR InterPro; IPR015517; dCMP_deaminase-rel.
DR InterPro; IPR035105; Deoxycytidylate_deaminase_dom.
DR PANTHER; PTHR11086:SF18; CYTIDINE AND DCMP DEAMINASE DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR11086; DEOXYCYTIDYLATE DEAMINASE-RELATED; 1.
DR Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR PIRSF; PIRSF006019; dCMP_deaminase; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR006019-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000255523};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR006019-2}.
FT DOMAIN 8..144
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
FT ACT_SITE 79
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006019-1"
FT BINDING 77
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR006019-2"
FT BINDING 102
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR006019-2"
FT BINDING 105
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR006019-2"
SQ SEQUENCE 169 AA; 18967 MW; 4AAB6AE718023C1E CRC64;
MKRSNVLSWD QYFMAMAHLS AKRSKDPNTQ VGACIVNAQK RVVGLGYNGF PKGCDDDEFP
WERDGEFLKT KYPYVVHAEL NAILNSIQDL NGCTIYVSLF PCNECAKAII QSGIRCVVYE
SDKYNGTDEN IASKRMFRDA GVELVQLTYE TSVDVQVNRS MTEAKDAAD
//
