ID   A0A380MCU2_9ACTO        Unreviewed;      1400 AA.
AC   A0A380MCU2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=ATP-dependent RNA helicase HrpA {ECO:0000313|EMBL:SUO88240.1};
GN   ORFNames=NCTC5224_01948 {ECO:0000313|EMBL:SUO88240.1};
OS   Trueperella pyogenes.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Trueperella.
OX   NCBI_TaxID=1661 {ECO:0000313|EMBL:SUO88240.1, ECO:0000313|Proteomes:UP000254485};
RN   [1] {ECO:0000313|EMBL:SUO88240.1, ECO:0000313|Proteomes:UP000254485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC5224 {ECO:0000313|EMBL:SUO88240.1,
RC   ECO:0000313|Proteomes:UP000254485};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UHHW01000002; SUO88240.1; -; Genomic_DNA.
DR   Proteomes; UP000254485; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:SUO88240.1};
KW   Hydrolase {ECO:0000313|EMBL:SUO88240.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          61..224
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          273..456
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1400 AA;  155477 MW;  0C0365A7DC26A3ED CRC64;
     MTTNENPAKH TKRTPGTRRT KRTPRGPRPF TPAELQARRD AVPTITYPAQ LPVSARKADI
     AAAIEHNQVV ILAGETGSGK TTQLPKICLE LGRGITGMIG HTQPRRIAAR SVADRICEEL
     GVQLGEAIGY QVRFTERVSR TTLVKLMTDG ILLAETQSDP ELRKYDTIII DEAHERSLNI
     DFLLGYLANL LPRRPDLKVI ITSATIDSQR FAEHFGRHMY GGFPGNEAPI IEVSGRTFPV
     EIRYRPLYDD GAADLSSLDE GRERLSREES RDQITGILDA AHELMAEGPG DILVFLSGEG
     EIRDTAKAFA EELGNRYIEP GGRSSVPDAV EVLPLFARLS GAEQQRIFQS RRHRRIILAT
     NIAETSLTVP GIRYVIDPGT ARISRYSNKT KVQRLPIEAI SQASANQRSG RSGRVQDGIA
     IRLYSEEDFA ARPEFTEPEI QRTSLAAVIL QMASMNLGSV EDFPFIDPPD MRAVRAGIQL
     LEEIGALAPM SAKAKGTAIG SGTHLLTDVG RTLARLPIDP RLGRMLLSAS EQGCAGEVLV
     LVAAMSVQDV RERPAEFKAQ ADQLHARFTD RTSDFLAYLN LWRYLRTQQR ELSGSAFRRM
     CRAEYLNWLR FREWQDVVAQ LRDMARPLGM DITPIALPTR AALARSASED KDNSHNQDVV
     RAVKELGQSA DTPAADQIHR SLLVGLLSNL GSWDERTKDY LGARGTRFVI WPGSGLHRRN
     PSWVMAAELV ETARLFARTV AQIKPEWVED VGNHLVRKQH SEPFWSTRQG AAMVHEKVTL
     YGLTLIADRK VLLSKVGMPA ARELAREMFI RHGLVDNQWR AHHAFIKHNK DALDQAREVE
     QRLRQVGLVA DDDAQFVFFD ERIPANIVSG RHFDTWWKRE RHKNPELLNF TQEFLLGQNS
     ADDDAFPDTW IQRDIALPIE YVYTPGSHAD GLSIDVPVTL LPQLTDDGFD WLVPGMLDEL
     VVATIRALPK PVRRHLVPAP DTAREILARL PQWDDVAHGQ LGAPSFRQAF NDAVAALRGV
     EITPEQWAEA TLPPHLEITF RVRSERGAVL DESTSITDLQ RRLAPQTRTA VESVVKGAVA
     QALEEARAQL LAQPTPAAQP NLEDNLHAWP DTDELPALVE TSGPHGMAVR GYPALVEVAG
     SRSVSLKVLA EPAEQVRDHR LGVIRLLATE LALPEGRVTS RWTGEESLTM AAAPYRSTAD
     VVDDLHKAAA RNIADQWAKA NDKPLGRLRT RADYTALRDH VRNLLEDEIY ALVKVAVRVL
     RAYGEADAKV RAGSSLALIN TVADVREQID ALVYDGFLAA TESDRLVHLV RYLQAAALRV
     DKAARGPAAD DAAAWQVHEM EDLLADQVEA AGRRAYDPRR AATLRQARWM IEELRVSLFA
     QQLGTAGKVS PQRIRKLLAS
//