ID   A0A380MQY8_9GAMM        Unreviewed;      1562 AA.
AC   A0A380MQY8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Leukotoxin {ECO:0000313|EMBL:SUO93717.1};
GN   Name=lktA {ECO:0000313|EMBL:SUO93717.1};
GN   ORFNames=NCTC13337_00365 {ECO:0000313|EMBL:SUO93717.1};
OS   Suttonella ornithocola.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cardiobacteriales;
OC   Cardiobacteriaceae; Suttonella.
OX   NCBI_TaxID=279832 {ECO:0000313|EMBL:SUO93717.1, ECO:0000313|Proteomes:UP000254601};
RN   [1] {ECO:0000313|EMBL:SUO93717.1, ECO:0000313|Proteomes:UP000254601}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13337 {ECO:0000313|EMBL:SUO93717.1,
RC   ECO:0000313|Proteomes:UP000254601};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; UHIC01000001; SUO93717.1; -; Genomic_DNA.
DR   RefSeq; WP_072577003.1; NZ_LWHB01000124.1.
DR   OrthoDB; 6713554at2; -.
DR   Proteomes; UP000254601; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 6.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR006644; Cadg.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR010566; Haemolys_ca-bd.
DR   InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR   InterPro; IPR001343; Hemolysn_Ca-bd.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003995; RTX_toxin_determinant-A.
DR   InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR   PANTHER; PTHR38340; S-LAYER PROTEIN; 1.
DR   PANTHER; PTHR38340:SF1; S-LAYER PROTEIN; 1.
DR   Pfam; PF06594; HCBP_related; 1.
DR   Pfam; PF05345; He_PIG; 3.
DR   Pfam; PF00353; HemolysinCabind; 7.
DR   PRINTS; PR00313; CABNDNGRPT.
DR   PRINTS; PR01488; RTXTOXINA.
DR   SMART; SM00736; CADG; 3.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF51120; beta-Roll; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 3.
DR   PROSITE; PS00330; HEMOLYSIN_CALCIUM; 9.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000254601};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          1119..1200
FT                   /note="Dystroglycan-type cadherin-like"
FT                   /evidence="ECO:0000259|SMART:SM00736"
FT   DOMAIN          1201..1293
FT                   /note="Dystroglycan-type cadherin-like"
FT                   /evidence="ECO:0000259|SMART:SM00736"
FT   DOMAIN          1294..1386
FT                   /note="Dystroglycan-type cadherin-like"
FT                   /evidence="ECO:0000259|SMART:SM00736"
SQ   SEQUENCE   1562 AA;  168548 MW;  08CDCD2C770B26BA CRC64;
     MDWIISDLTI FQRKEDKKYV VALKGTQGFF EDILPTDIKD IVFDGLAHKQ LIDMYNFWQQ
     IKAPKGQSYT VATATVIDDL SNKLNVLIEL KNIPGNRPAD ILIKEQIEKI YQQAHEMGYV
     IDETVNGGAV YAINFAQSDN VYHDERAYGL GINPEQVIVT GHSLGGHLSA AFSRLFADVV
     EHAYMINGAG FGRETSIVSS YADKNVQQFF AALGGQDKFD ADKITNFIGD KNIDVTANNW
     EVGLKQPGAT PELFIESGTE KLGHTVTQMT DTMTVIELFT RLDASLQTKP IADLLKMMNT
     MLKASSKDDT LTLETVVNKL GAFLPLNENV QITANDREAL HNKIHAIKEY IDKEGEKEHL
     DIRFRLIDES ILQTALSKDV AYDETMAARY ALKQLNPFIV NSDTLYKEDS LLKDALSKLK
     LWSSEDINVV REAIHEPYVT ETYLTDRAAM LHNFIADNTT NAIPNRYYHD VDSKISVGEE
     AYYTYPGRDD VPKVLFGSDR EDAPDHLVGG DKKDHLFGGA GDDVLDGGKG DDYLEGGLGF
     DTYYIQDHDT VLDVDLSGKL VFKGKENLDF TDTVFKKAFV APVENEVLWL SSKGDLGAIQ
     KQDTKDLAVR YDGSSAMIKE FFTLSEAHGH GVSSAGDKKA NSWQGLGLTL TDEGDDVPSF
     EYRHLEMVKH KFGSVIAGGE HFSVAGSNKL DSIMLLGAKE SVVQAGLGND VVYGSGYADY
     LYGDAGNDII FGSAKAQGKA TGADDDHIFG GAGNDLIHGG AGDDVIYADD EAAAFAIQAA
     DKGDWLLGGE GMDTLYGAQG TDFINGGAGV DVVYGGAGDD VILGDGEVVF SPKYASINTY
     SPPTYMPSPS PWISPHWTPA YISAYDYTFN TEKNTFDKAP LSYMRVPKVP TFDWVLSIDA
     VSGDYQVSAE NVDGQSQHRV AEGGASDYLY GGAGNDLIIG QDGDDYLHGG EGDDILWGDD
     NRDVSVSGDD TLLGGAGDDR LYGGKGRDSL FGGAGSDRLE GGEGADNYYF YADEFVDGSI
     DVLKDAGSGA ENGGVDLIYL DNRLIFSYRW LVDADAPNQW VSDGGYRLAL EGDTLTLSHQ
     GSAGKVQILD FADGDYGLFL QAQNHAPEVA EQAPAIKGTV AGALNVVFSE ALFSDADGDV
     LRYRMEGLPQ GLAFDADTRT LTGTVAQAGE YHLRLIASDA HGASAEQLVS LTVVPVNHAP
     VVNEAVAAVQ GDTENALNVV FSAALFKDAD GDVLRYRMEG LPEGLVFDAD TRTLSGVAKQ
     AGAYEARLIA SDGKGGEVSQ VVPLEIVFIN HAPEVQTPIP TQSLTLREDW HFQLPSDSVI
     DADGDVLSYA LGEGAPSWMN VTTDGALSAS PVSTGDYHVP IVVSDTHGAS ATLNLDVTVN
     VPENTKVSEG LSFGGFGDDR IFGSEQDDTL RGLIGNDELF GFGGNDHLVG GIGNDVLDGG
     AGEDTLEGGL GNDRLVGGAG NDWLYGGFGD DVYVFARGDG QDVIRDSGGQ DTLVLTDFRL
     EDVLFSHQNG NLMLHAKDSE DGITIKNWSS WFASGKIEKF VFNDQSYSYQ QIKDYVSGIE
     IV
//