ID A0A380TVG0_9PAST Unreviewed; 782 AA.
AC A0A380TVG0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:SUT91771.1};
GN ORFNames=NCTC10801_01530 {ECO:0000313|EMBL:SUT91771.1};
OS [Actinobacillus] rossii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae.
OX NCBI_TaxID=123820 {ECO:0000313|EMBL:SUT91771.1, ECO:0000313|Proteomes:UP000254649};
RN [1] {ECO:0000313|EMBL:SUT91771.1, ECO:0000313|Proteomes:UP000254649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10801 {ECO:0000313|EMBL:SUT91771.1,
RC ECO:0000313|Proteomes:UP000254649};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UFRQ01000003; SUT91771.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A380TVG0; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000254649; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 539..720
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 782 AA; 88571 MW; 192CA9D23D67A61B CRC64;
MHIHLDKLAL IVIVMALTLQ WTPAFLLFPW QHWGLVILPI FLIAFGYRHL SRRLSSIFFY
VSFALGCLAY FQHSALQDYL AAKAIEPQQV RIEIRIDEIL QQQAYQTLIV STKNSQRIYL
QWRLNEKPKI GERWQADLRI RPLSSRLNQG GFDRQKWYFS KGIHATATVK SAVKISDDFS
WRERQLHQAF AQTKALAQQG LLLALGFGER AWLNPETWSI YQKTNTAHLI AISGLHIGLA
MFLGFGIARV IQFVFPLKWI TPLFPILVGI ALAVVYAELA GFAIPTFRAI VSLLLITLVK
LQRGYYTPWQ LFVFVIAVLL ICDPIMVLSA SFWLSVGAVA SLILWYQVFP FHLIQWQGQP
LPIKVRWILG LIHLQLGLFW LFTPIQLMIF DGFAFNGLIA NLIAVPLYSF LLVPVTLFAA
LTHGVAYSWQ IADFLAGQIT AVVQLFQGSW IIFSESQTLI FIAFLALIFV TLMNWTYGKI
ASKSQYHYFN LDPCRSFSIK SRKRINFIGF SIVIFCISML LFHKITPKNW RVETLDVGQG
LATLIVKNAR GVLYDTGASW VNGSMAKSEI IPYLQRKGIE LDWLILSHDD NDHSGGAQDI
LAYSQLKLLT PSNQNKDKTD RTFCIVGKTW QWEGLTFSVL SPDHITERAE NADSCVILIS
DGQFNVLLTG DADIATEQRI LANLPKIDVL QVGHHGSQTS TGSKFVQHIR PDISLISSSR
WNPWHFPHKD VVARLENAGS AVKNTAVLGQ ISVIFDKTGM QIQSARSDFS PWYRGFIGEI
AK
//
