ID A0A381E0P4_9GAMM Unreviewed; 271 AA.
AC A0A381E0P4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=tRNA pseudouridine synthase C {ECO:0000256|ARBA:ARBA00040675};
DE EC=5.4.99.26 {ECO:0000256|ARBA:ARBA00038943};
DE AltName: Full=tRNA pseudouridine(65) synthase {ECO:0000256|ARBA:ARBA00041975};
DE AltName: Full=tRNA pseudouridylate synthase C {ECO:0000256|ARBA:ARBA00043049};
DE AltName: Full=tRNA-uridine isomerase C {ECO:0000256|ARBA:ARBA00041803};
GN Name=truC {ECO:0000313|EMBL:SUX19466.1};
GN ORFNames=NCTC13294_00520 {ECO:0000313|EMBL:SUX19466.1};
OS Cardiobacterium valvarum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cardiobacteriales;
OC Cardiobacteriaceae; Cardiobacterium.
OX NCBI_TaxID=194702 {ECO:0000313|EMBL:SUX19466.1, ECO:0000313|Proteomes:UP000254572};
RN [1] {ECO:0000313|EMBL:SUX19466.1, ECO:0000313|Proteomes:UP000254572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13294 {ECO:0000313|EMBL:SUX19466.1,
RC ECO:0000313|Proteomes:UP000254572};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC transfer RNAs. {ECO:0000256|ARBA:ARBA00037670}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC Evidence={ECO:0000256|ARBA:ARBA00036607};
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DR EMBL; UFUW01000001; SUX19466.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A381E0P4; -.
DR OrthoDB; 9785808at2; -.
DR Proteomes; UP000254572; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF56; TRNA PSEUDOURIDINE SYNTHASE C; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:SUX19466.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000254572};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 14..174
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
SQ SEQUENCE 271 AA; 30457 MW; 79119E0F2353E781 CRC64;
MLSPLAILYR DDRLLAVNKP AGLFVHPSPL DRYAASSVVE QLQQQIGCKP YPVHRLDRPT
SGVLLFALDP ETARLCGAHI AANRLHKTYH AVVRGWLADA GNIDYPLSYL PDKIADRDRS
RDKAPQAALT HYRCLRRSEI PLASDGRHPT SRYSLAELNP RHGRKHQLRR HLKHIFHPIL
GDTSHGDNRQ NRVLGGHLGD PRYTTAMTGP GLRLMLHATR LQFPHPWSGE ALDLRAPPDA
HWQYISRYLG LETAFSEPHA KNCSDGIGRC S
//
