ID A0A381EAV9_9GAMM Unreviewed; 605 AA.
AC A0A381EAV9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Peptidoglycan synthase FtsI {ECO:0000313|EMBL:SUX24144.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:SUX24144.1};
GN Name=ftsI_2 {ECO:0000313|EMBL:SUX24144.1};
GN ORFNames=NCTC13294_01716 {ECO:0000313|EMBL:SUX24144.1};
OS Cardiobacterium valvarum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cardiobacteriales;
OC Cardiobacteriaceae; Cardiobacterium.
OX NCBI_TaxID=194702 {ECO:0000313|EMBL:SUX24144.1, ECO:0000313|Proteomes:UP000254572};
RN [1] {ECO:0000313|EMBL:SUX24144.1, ECO:0000313|Proteomes:UP000254572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13294 {ECO:0000313|EMBL:SUX24144.1,
RC ECO:0000313|Proteomes:UP000254572};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UFUW01000001; SUX24144.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A381EAV9; -.
DR OrthoDB; 9789078at2; -.
DR Proteomes; UP000254572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000313|EMBL:SUX24144.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000256|ARBA:ARBA00022645};
KW Reference proteome {ECO:0000313|Proteomes:UP000254572};
KW Transferase {ECO:0000313|EMBL:SUX24144.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 34..220
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 262..557
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 582..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 66400 MW; 6532C6686528FFFD CRC64;
MTLLLIGQLI RLQVTTAREL TARGYDRSLR IQTEDALRGF IFDREGEPLA ISTPVSTLIA
DPTRLWATLN GDFDRLREAC LSDKNYSEDC SWVNSGDEEE TRLRYHYEIL RPLAGLLDED
LARFYDELVK RGDSQFMYLA RQIPPNIAKE AMDLKIPALR QENGYKRFYP SGEIMGQIIG
YTDVEDKGQE GLEKLYENTL AGRPGKMKIL QDRAGRALRV VEEVAPAAKG SQLQLSIDKR
IQFITHQVLQ DTMNQYRAAS VTAVVIDIKS GEILAMVSLP AGNPNVSAER RAELLKNRAV
TDTFEPGSTM KPLAVAAAIE LGAISPNTRF KKGMTYQMGK NTVRDTHNYG TQDTVGIIRK
SSNVGMAMIS ERTPRKKYRA FMHELGFGEP SGINFPGEQR GHFPRTEKLG NFEYATIFYG
YGVSTSALQL AHAYATIAND GVAMPLSLLK VHTPPEGKRV MSAKTAASVR KMLEAVVGDG
GTGRRANTDT YTVAGKTGTS HKVRAGGGYA EKNYRGIFAG YAPAHDPRIA MVVVVDDPKG
SDYYGGLVAA PPFARIAEAS LKMLNVLPDK ITKTDAIALV SDSGDPFEDN DTVGAPDVPA
KEITQ
//
