ID   A0A383S3U5_9ACTN        Unreviewed;       659 AA.
AC   A0A383S3U5;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Penicillin binding protein transpeptidase domain {ECO:0000313|EMBL:SYZ32670.1};
GN   ORFNames=PROPAUS_0559 {ECO:0000313|EMBL:SYZ32670.1};
OS   Propionibacterium australiense.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Propionibacterium.
OX   NCBI_TaxID=119981 {ECO:0000313|EMBL:SYZ32670.1, ECO:0000313|Proteomes:UP000263928};
RN   [1] {ECO:0000313|Proteomes:UP000263928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hornung B.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
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DR   EMBL; UNQJ01000002; SYZ32670.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A383S3U5; -.
DR   Proteomes; UP000263928; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000263928};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          102..283
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          328..633
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   659 AA;  69773 MW;  D5146D7997DA98B1 CRC64;
     MASSDRTGAG GGRSGSRRAS SSYRSSPARR SPSRGSSARS HGASSSGFRM RLGSTTFRLR
     ASMIVLALVL SLLAGRAFQL QGLDSAANAQ AAAEKMTHTR TIKATRGSVL DRNGAVLATT
     QPAVKVIADP ASISVNGYNA DNLTDEQLAD LAERTPHQVA EVLVNFLGGA TTDYLPALTR
     TTTDDGSVNQ YEVLKEEVVA DTYEQLRQAL DEVTDVLGNR GLYGITSEDD PIRVYPSGTL
     ASNIVGFVNA EGTGAGGFEY YADERLAGTD GYEQYESGHY GRIPLADNTL KEAVDGTTYA
     LTIDSELQYS AQQLIAAEAA KYSALSASTV IMNVKTGEIL ALATTPGYDS NDPGAANPDD
     LGNRAISEAY EPGSVAKVFT NAVLFDRGLA NPDTKVEVPA SIASGDNEIR DSDRHADTKH
     YTARGVFYHS SNIGSALLLR QLDSATYQQY MTDLGFGSAS GVELPGEAEG YLPGESMADY
     TRDNMAFGQG FSTNVVQMAA ALAAVTNGGV YHQPTIISSA TDANGTAVSL PERASRRVIS
     EQASAEVLDI MEAVTAGGAG QESRMISGYR MGGKSGTAQM IDEETGQYDA HRYMSSYVTV
     APIEDPQVLV YTVVEVQDQY GGTVAMPTSR MLMSMALPRY GVLPSAEVPI DTEPLEYEP
//