ID A0A383S5F4_9ACTN Unreviewed; 843 AA.
AC A0A383S5F4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=AAA family ATPase {ECO:0000313|EMBL:RLP10206.1};
DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit signature {ECO:0000313|EMBL:SYZ33210.1};
GN ORFNames=D7U36_06470 {ECO:0000313|EMBL:RLP10206.1}, PROPAUS_1127
GN {ECO:0000313|EMBL:SYZ33210.1};
OS Propionibacterium australiense.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Propionibacterium.
OX NCBI_TaxID=119981 {ECO:0000313|EMBL:SYZ33210.1, ECO:0000313|Proteomes:UP000263928};
RN [1] {ECO:0000313|Proteomes:UP000263928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hornung B.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SYZ33210.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Propionibacterium_australiense1 {ECO:0000313|EMBL:SYZ33210.1};
RA Ferrada E.E., Latorre B.A.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RLP10206.1, ECO:0000313|Proteomes:UP000279336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML98A078 {ECO:0000313|EMBL:RLP10206.1,
RC ECO:0000313|Proteomes:UP000279336};
RA Bernier A.-M., Bernard K.;
RT "Propionibacterium australiense Genome Sequencing and Assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; RCIW01000008; RLP10206.1; -; Genomic_DNA.
DR EMBL; UNQJ01000006; SYZ33210.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A383S5F4; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000263928; Unassembled WGS sequence.
DR Proteomes; UP000279336; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Hydrolase {ECO:0000313|EMBL:SYZ33210.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:SYZ33210.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000263928};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 2..144
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 425..460
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 149..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 92810 MW; 4840C5717D53B889 CRC64;
MFERFTDRAR RVIVLAQDEA KMLNHNYIGT EHILLGLIHE GEGVAAKALE QLGISLEAVR
EQVEEIIGHG QNPPTGHIPF TPRAKKVLEL SLREALQMNH SYIGTEHILL GLIREGEGVA
AQVLIKLGAD LNRVRTTVLA LLSGYQEESG AQPATAGAPE APSSSPSNST LDQFGRNLTQ
AAREGSLDPV IGRQKEIERV MTVLSRRTKN NPVLIGEPGV GKTAVVEGLA QAIVRGDVPE
TLRNHQIYSL DLGALVAGSR YRGDFEERLK KVLKEIKTRG DIVLFIDEIH TLVGAGAAEG
AIDAASILKP MLARGELQTI GATTLDEYRK HIEKDAALER RFQPIQVDEP SIPLTIEILK
GLRDRYEAHH KVTITDEALT AAANLADRYV QDRFLPDKAI DLIDEAGARL RIARMTAPPD
LREFDERLAG VRAEKESAID HQDFEAAAKL RDDERKILAA RAEKEAAWKE GASDVPAIIG
EEEIAEVLSS STGVPVSRLT EAESQRLLHM EDELHKRYIG QDEAVKAISR SIRRTRAGLK
DPNRPSGSFI FAGPSGVGKT ELTKALTEFL FGDEDALITL DMSEYSEKHT ASRMFGSPPG
YVGYEEGGQL TEKVRRKPFS VILFDEIEKA HPDIFNSLLQ ILDEGRLTDA QGRVVDFKNT
VIVMTTNLGS RDISRTVNLG FSRAGDTESG YDAMKAKVSE ELKTHFRPEF LNRVDEVVVF
HQLTQDDILR IVDLMVGQIE KRLSERDMSI ELTDAAKQLI GRRGFDPVLG ARPLRRAIQR
DIEDPISERI LYSELKPGEI VVVDVAEGAD EKSSEPFTFA GTPKAAVADA DLVQLTGGDA
PQE
//
